Chan Y K, Li E K, Tam L S, Chow L T C, Ng H K
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PRC.
Scand J Rheumatol. 2003;32(5):306-8. doi: 10.1080/03009740310003956.
We describe a Chinese woman who developed severe heart failure 3 years from the onset of systemic lupus erythematosus (SLE). Endomyocardial biopsy confirmed lupus myocarditis, with focal infiltrates of small lymphocytes and some polymorphic neutrophils. The conventional treatment for cardiac failure plus oral prednisolone failed to bring clinical and echocardiographical improvement until the addition of intravenous (i.v.) 'pulse' cyclophosphamide. Three weeks after i.v. cyclophosphamide treatment, there was significant improvement of her heart failure symptoms with improvement in the ejection fraction from 19% to 63%.
我们描述了一名中国女性，她在系统性红斑狼疮（SLE）发病3年后出现严重心力衰竭。心内膜心肌活检证实为狼疮性心肌炎，有小淋巴细胞和一些多形核中性粒细胞的局灶性浸润。常规的心力衰竭治疗加口服泼尼松龙未能带来临床和超声心动图改善，直到加用静脉注射“脉冲”环磷酰胺。静脉注射环磷酰胺治疗三周后，她的心力衰竭症状有显著改善，射血分数从19%提高到63%。
