血管功能与中风中的催产素受体信号传导
Oxytocin Receptor Signaling in Vascular Function and Stroke.
作者信息
McKay Erin C, Counts Scott E
机构信息
Department of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Neuroscience Program, Michigan State University, East Lansing, MI, United States.
出版信息
Front Neurosci. 2020 Sep 25;14:574499. doi: 10.3389/fnins.2020.574499. eCollection 2020.
Abstract
The oxytocin receptor (OXTR) is a G protein-coupled receptor with a diverse repertoire of intracellular signaling pathways, which are activated in response to binding oxytocin (OXT) and a similar nonapeptide, vasopressin. This review summarizes the cell and molecular biology of the OXTR and its downstream signaling cascades, particularly focusing on the vasoactive functions of OXTR signaling in humans and animal models, as well as the clinical applications of OXTR targeting cerebrovascular accidents.
摘要
催产素受体（OXTR）是一种G蛋白偶联受体，具有多种细胞内信号通路，这些信号通路在与催产素（OXT）和一种类似的九肽抗利尿激素结合后被激活。本综述总结了OXTR及其下游信号级联反应的细胞和分子生物学，特别关注OXTR信号在人类和动物模型中的血管活性功能，以及靶向OXTR治疗脑血管意外的临床应用。
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