Mesia-Vela S, Santos M T, Souccar C, Lima-Landman M T R, Lapa A J
Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.
Phytomedicine. 2002 Sep;9(6):508-14. doi: 10.1078/09447110260573137.
Solanum paniculatum L. is used commonly in Brazilian folk medicine for the treatment of liver and gastrointestinal disorders. The freeze-dried aqueous extracts (WEs) obtained from distinct parts of the plant (flowers, fruits, leaves, stems and roots) were tested to determine their antiulcer and antisecretory gastric acid activities using mice. The aqueous extracts of roots, stems and flowers inhibited gastric acid secretion in pylorus-ligated mice with ED50 values of 418, 777 and 820 mg/kg body wt. (i.d.), respectively. Extracts of leaves (0.5-2 g/kg body wt., i.d.) did not affect gastric secretion, whereas fruit extracts (0.5-2 g/kg body wt., i.d.) stimulated gastric acid secretion. The stimulatory effect of the fruit extract was inhibited by pretreatment with atropine (5 mg/kg body wt., i.m.) but not with ranitidine (80 mg/kg body wt., i.p.) suggesting that the fruit extract activates the muscarinic pathway of gastric acid secretion. In contrast, administration of the root extract into the duodenal lumen inhibited histamine- and bethanechol-induced gastric secretion in pylorus-ligated mice. In addition, the aqueous extract of roots (ED50 value, 1.2 g/kg body wt., p.o.) protected the animals against production of gastric lesions subsequent to the hypersecretion induced in mice by stress following cold restraint. This effect was not reproduced when the lesions were induced by blockade of prostaglandins synthesis via subcutaneous injection of indomethacin. Thus, antiulcer activity of the plant extracts appears to be related directly to a potent anti-secretory activity. No toxic signs were observed following administration of different extracts up to 2 g/kg body wt., p.o. Collectively, the results validate folk use of Solanum paniculatum L. plant to treat gastric disorders.
刺茄在巴西民间医学中常用于治疗肝脏和胃肠道疾病。从该植物不同部位（花、果实、叶、茎和根）获得的冻干水提取物，用小鼠进行了抗溃疡和胃酸分泌抑制活性测试。根、茎和花的水提取物抑制幽门结扎小鼠的胃酸分泌，其半数有效剂量（ED50）分别为418、777和820mg/kg体重（腹腔注射）。叶提取物（0.5 - 2g/kg体重，腹腔注射）不影响胃酸分泌，而果实提取物（0.5 - 2g/kg体重，腹腔注射）刺激胃酸分泌。果实提取物的刺激作用可被阿托品（5mg/kg体重，肌肉注射）预处理抑制，但不能被雷尼替丁（80mg/kg体重，腹腔注射）抑制，这表明果实提取物激活了胃酸分泌的毒蕈碱途径。相反，将根提取物注入十二指肠腔可抑制幽门结扎小鼠中组胺和氨甲酰甲胆碱诱导的胃酸分泌。此外，根的水提取物（半数有效剂量值为1.2g/kg体重，口服）可保护动物免受冷束缚应激诱导的小鼠胃酸分泌过多后产生的胃损伤。当通过皮下注射吲哚美辛阻断前列腺素合成诱导损伤时，这种效果未再现。因此，植物提取物的抗溃疡活性似乎与强大的分泌抑制活性直接相关。口服给予高达2g/kg体重的不同提取物后未观察到毒性迹象。总体而言，这些结果证实了刺茄在民间用于治疗胃部疾病的用途。
