King Saud University, Faculty of Pharmacy, Pharmacognosy Department, Saudi Arabia.
Saudi Pharm J. 2012 Oct;20(4):371-9. doi: 10.1016/j.jsps.2012.05.010. Epub 2012 Jun 5.
Chemical reinvestigation of the aerial parts of Solanum schimperianum Hochst led to the isolation of ten compounds, lupeol (1), β-sitosterol (2), β-sitosterol glucoside (3), oleanolic acid (4), teferidin (5), teferin (6), ferutinin (7), 5-hydroxy-3,7,4'-trimethoxyflavone (8), retusin (9) and kaempferol-3-O-β-d-glucopyranoside (10). Compounds 5-7 were isolated for the first time from Solanaceae and compounds 1-4 and 8-9 for the first time from Solanum schimperianum. The structure elucidation of the isolated compounds was based on careful inspection of spectral data including 1D ((1)H and (13)C NMR), 2D ((1)H-H COSY, HMQC and HMBC, ROESY), UV, MS and IR, in addition to, comparison with literatures. The antimicrobial activity of the extracts as well as the isolated compounds was tested. Only hexane extract showed activity against Bacillus subtilus and Staphylococcus aureus.
对龙葵（Solanum schimperianum Hochst）地上部分进行化学再研究，分离得到了 10 种化合物，分别为：羽扇豆醇（1）、β-谷甾醇（2）、β-谷甾醇葡萄糖苷（3）、齐墩果酸（4）、特飞灵（5）、特飞宁（6）、荞麦碱（7）、5-羟基-3,7,4'-三甲氧基黄酮（8）、雷杜辛（9）和山奈酚-3-O-β-D-吡喃葡萄糖苷（10）。化合物 5-7 首次从茄科植物中分离得到，化合物 1-4 和 8-9 首次从龙葵中分离得到。通过仔细检查包括 1D（（1）H 和（13）C NMR）、2D（（1）H-H COSY、HMQC 和 HMBC、ROESY）、UV、MS 和 IR 在内的光谱数据，以及与文献的比较，对分离得到的化合物的结构进行了阐明。测试了提取物和分离化合物的抗菌活性。只有正己烷提取物对枯草芽孢杆菌和金黄色葡萄球菌表现出活性。
