索兰尼果化学成分与生物活性研究
Phytochemical and biological studies of Solanum schimperianum Hochst.
机构信息
King Saud University, Faculty of Pharmacy, Pharmacognosy Department, Saudi Arabia.
出版信息
Saudi Pharm J. 2012 Oct;20(4):371-9. doi: 10.1016/j.jsps.2012.05.010. Epub 2012 Jun 5.
Abstract
Chemical reinvestigation of the aerial parts of Solanum schimperianum Hochst led to the isolation of ten compounds, lupeol (1), β-sitosterol (2), β-sitosterol glucoside (3), oleanolic acid (4), teferidin (5), teferin (6), ferutinin (7), 5-hydroxy-3,7,4'-trimethoxyflavone (8), retusin (9) and kaempferol-3-O-β-d-glucopyranoside (10). Compounds 5-7 were isolated for the first time from Solanaceae and compounds 1-4 and 8-9 for the first time from Solanum schimperianum. The structure elucidation of the isolated compounds was based on careful inspection of spectral data including 1D ((1)H and (13)C NMR), 2D ((1)H-H COSY, HMQC and HMBC, ROESY), UV, MS and IR, in addition to, comparison with literatures. The antimicrobial activity of the extracts as well as the isolated compounds was tested. Only hexane extract showed activity against Bacillus subtilus and Staphylococcus aureus.
摘要
对龙葵（Solanum schimperianum Hochst）地上部分进行化学再研究，分离得到了 10 种化合物，分别为：羽扇豆醇（1）、β-谷甾醇（2）、β-谷甾醇葡萄糖苷（3）、齐墩果酸（4）、特飞灵（5）、特飞宁（6）、荞麦碱（7）、5-羟基-3,7,4'-三甲氧基黄酮（8）、雷杜辛（9）和山奈酚-3-O-β-D-吡喃葡萄糖苷（10）。化合物 5-7 首次从茄科植物中分离得到，化合物 1-4 和 8-9 首次从龙葵中分离得到。通过仔细检查包括 1D（（1）H 和（13）C NMR）、2D（（1）H-H COSY、HMQC 和 HMBC、ROESY）、UV、MS 和 IR 在内的光谱数据，以及与文献的比较，对分离得到的化合物的结构进行了阐明。测试了提取物和分离化合物的抗菌活性。只有正己烷提取物对枯草芽孢杆菌和金黄色葡萄球菌表现出活性。
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本文引用的文献
1
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Afr J Tradit Complement Altern Med. 2006 Nov 13;4(2):240-4. doi: 10.4314/ajtcam.v4i2.31214.
2
Antiplasmodial and antitrypanosomal activity of plants from the Kingdom of Saudi Arabia.沙特阿拉伯王国植物的抗疟和抗锥虫活性
J Nat Med. 2009 Apr;63(2):232-9. doi: 10.1007/s11418-008-0305-5. Epub 2008 Dec 10.
3
Antiinflammatory activity of Solanum trilobatum.刺天茄的抗炎活性。
Fitoterapia. 2006 Dec;77(7-8):611-2. doi: 10.1016/j.fitote.2006.09.009. Epub 2006 Sep 23.
4
Studies on hypoglycaemic activity of Solanum xanthocarpum Schrad. & Wendl. fruit extract in rats.黄果茄果实提取物对大鼠的降血糖活性研究。
J Ethnopharmacol. 2006 Nov 24;108(2):251-6. doi: 10.1016/j.jep.2006.05.016. Epub 2006 May 26.
5
Effect of Solanum lycocarpum St. Hill on various haematological parameters in diabetic rats.番茄（Solanum lycocarpum St. Hill）对糖尿病大鼠各项血液学参数的影响。
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6
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Neurotoxicol Teratol. 2005 Nov-Dec;27(6):861-70. doi: 10.1016/j.ntt.2005.07.001. Epub 2005 Aug 15.
7
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9
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10
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