Blodgett Jordan, Wang Yan, Li Tingyu, Polavarapu Prasad L, Drabowicz Jozef, Pietrusiewicz K Michal, Zygo Krystyna
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235-1822, USA.
Anal Chem. 2002 Oct 15;74(20):5212-6. doi: 10.1021/ac0203443.
Resolution of racemic tert-butyl-1-(2-methylnaphthyl)-phosphine oxide 1, a chiral phosphorus compound, was achieved using selectors developed from a small peptide library. Separation factors as high as 3.2 were observed. The library consists of 81 peptide-based potential chiral selectors on polymeric synthesis resins. The linker needed to immobilize the identified chiral selectors onto silica gel proved important in the chiral separation; a longer linker provided a significantly higher separation factor in this study.
使用从小肽库开发的选择剂实现了手性磷化合物外消旋叔丁基-1-(2-甲基萘基)氧化膦1的拆分。观察到分离因子高达3.2。该库由基于肽的81种潜在手性选择剂组成，这些选择剂位于聚合物合成树脂上。将鉴定出的手性选择剂固定在硅胶上所需的连接体在手性分离中被证明很重要；在本研究中，较长的连接体提供了显著更高的分离因子。
