Li Tingyu
Department of Chemistry, Mississippi State University, MS 39762, USA.
J Sep Sci. 2005 Oct;28(15):1927-31. doi: 10.1002/jssc.200500194.
The application of peptide and peptidomimetic chiral selectors in LC is reviewed in this article. In particular, methods for finding these types of selectors using combinatorial library approaches are discussed, as well as recent advances in the use of peptides and peptidomimetics as general chiral selectors for LC. In terms of the library approaches, batch screening and reciprocal screening are discussed. As for general chiral selectors, one example involves the application of chiral diamide phases. Another example shows the versatility of oligoproline chiral stationary phases, which exhibit resolution for a number of racemic analytes, comparable to other well-established chiral stationary phases.
本文综述了肽和拟肽手性选择剂在液相色谱中的应用。特别讨论了使用组合库方法寻找这类选择剂的方法，以及肽和拟肽作为液相色谱通用手性选择剂的最新进展。在库方法方面，讨论了批量筛选和交互筛选。至于通用手性选择剂，一个例子涉及手性二酰胺相的应用。另一个例子展示了寡聚脯氨酸手性固定相的多功能性，它对多种外消旋分析物具有分离能力，与其他成熟的手性固定相相当。
