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吗啡处理小鼠体内可存活但不可培养的沙门氏菌的复苏及全身感染

Viable but nonculturable Salmonella species recovery and systemic infection in morphine-treated mice.

作者信息

Asakura Hiroshi, Watarai Masahisa, Shirahata Toshikazu, Makino Sou-Ichi

机构信息

Department of Veterinary Microbiology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.

出版信息

J Infect Dis. 2002 Nov 15;186(10):1526-9. doi: 10.1086/344353. Epub 2002 Oct 23.

DOI:10.1086/344353
PMID:12404175
Abstract

In vivo recovery and pathogenicity of Salmonella enterica serovar Oranienburg that became viable but nonculturable (VNC) in food were examined. VNC cells were completely eliminated in normal mice but caused systemic bacteremia and were subsequently lethal to morphine-treated mice. Therefore, morphine-treated mice might be a useful bioassay for VNC Salmonella species in implicated food items.

摘要

对在食品中进入活的非可培养状态（VNC）的肠炎沙门氏菌血清型奥拉宁堡的体内恢复情况和致病性进行了研究。VNC细胞在正常小鼠体内被完全清除，但会引起全身性菌血症，随后对经吗啡处理的小鼠具有致死性。因此，经吗啡处理的小鼠可能是检测相关食品中VNC沙门氏菌的一种有用的生物测定方法。

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