• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-The Order of the Cyclization Steps This work was supported by the Deutsche Forschungsgemeinschaft (SFB 323) and by a grant of the EU (MEGATOP, QLK3-1999-00650). R. D. S. gratefully acknowledges the support of a Feodor-Lynen Fellowship granted by the Alexander-von-Humboldt Stiftung. We thank Corina Bihlmaier and Volker Pfeifer for help with transformation and Southern hybridization, J. A. Moss (La Jolla (USA)) for critical comments on the manuscript and Prof. Dr. M. E. Maier and Prof. Dr. H.-P. Fiedler (Tübingen) for generous support.

作者信息

Bischoff Daniel, Pelzer Stefan, Bister Bojan, Nicholson Graeme J., Stockert Sigrid, Schirle Markus, Wohlleben Wolfgang, Jung Günther, Süssmuth Roderich D.

机构信息

Institut für Organische Chemie Universität Tübingen Auf der Morgenstelle 18, 72076 Tübingen (Germany).

出版信息

Angew Chem Int Ed Engl. 2001 Dec 17;40(24):4688-4691. doi: 10.1002/1521-3773(20011217)40:24<4688::aid-anie4688>3.0.co;2-m.

DOI:10.1002/1521-3773(20011217)40:24<4688::aid-anie4688>3.0.co;2-m
PMID:12404385
Abstract
摘要

相似文献

1
The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-The Order of the Cyclization Steps This work was supported by the Deutsche Forschungsgemeinschaft (SFB 323) and by a grant of the EU (MEGATOP, QLK3-1999-00650). R. D. S. gratefully acknowledges the support of a Feodor-Lynen Fellowship granted by the Alexander-von-Humboldt Stiftung. We thank Corina Bihlmaier and Volker Pfeifer for help with transformation and Southern hybridization, J. A. Moss (La Jolla (USA)) for critical comments on the manuscript and Prof. Dr. M. E. Maier and Prof. Dr. H.-P. Fiedler (Tübingen) for generous support.
Angew Chem Int Ed Engl. 2001 Dec 17;40(24):4688-4691. doi: 10.1002/1521-3773(20011217)40:24<4688::aid-anie4688>3.0.co;2-m.
2
The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-New Insights into the Cyclization Steps This work was supported by the Deutsche Forschungsgemeinschaft (SFB 323). We thank M. Schierle, Dr. S. Stevanovic and Prof. H.-G. Rammensee for help with Edman degradation and J. Turner, Prof. B. List and Prof. D. Boger (La Jolla, USA) for discussions on the work.万古霉素类糖肽抗生素的生物合成——环化步骤的新见解 本研究得到德国研究基金会（SFB 323）的支持。我们感谢M. Schierle、S. Stevanovic博士和H.-G. Rammensee教授在埃德曼降解方面提供的帮助，以及J. Turner、B. List教授和D. Boger教授（美国拉霍亚）就本研究进行的讨论。
Angew Chem Int Ed Engl. 2001 May 4;40(9):1693-1696. doi: 10.1002/1521-3773(20010504)40:9<1693::aid-anie16930>3.0.co;2-8.
3
A Rapid Total Synthesis of Spirotryprostatin B: Proof of Its Relative and Absolute Stereochemistry F.v.N. gratefully acknowledges the Alexander-von-Humboldt-Stiftung for a Feodor-Lynen fellowship that was kindly backed by Dr. R. Breslow as second host. This research was supported by the National Institutes of Health (Grant number HL 25848). We thank Dr. H. Osada (RIKEN) for providing us with spectra of the natural product. Furthermore we are grateful to Dr. D. Lichtblau from the Nakanishi laboratory for help with the CD spectra. We acknowledge the collaborative efforts of Ms. Maria Manzoni in these studies.
Angew Chem Int Ed Engl. 2000 Jun 16;39(12):2175-2178. doi: 10.1002/1521-3773(20000616)39:12<2175::aid-anie2175>3.0.co;2-j.
4
Dehydrocoupling of Phosphanes Catalyzed by a Rhodium(I) Complex We thank the National Institutes of Health (NIH) for financial support and O. Daugulis for samples of dimesitylphosphane and 2,4,6-tri-tert-butylphenylphosphane. V.P.W.B. acknowledges a Feodor Lynen fellowship of the Alexander-von-Humboldt-Stiftung (Germany).
Angew Chem Int Ed Engl. 2001 Dec 17;40(24):4694-4696. doi: 10.1002/1521-3773(20011217)40:24<4694::aid-anie4694>3.0.co;2-7.
5
Structure and Dynamics of the Host-Guest Complex of a Molecular Tweezer: Coupling Synthesis, Solid-State NMR, and Quantum-Chemical Calculations S.P.B. thanks the Alexander von Humboldt Foundation for a research fellowship. C.O. acknowledges financial support by a Liebig "Habilitation" fellowship from the Fonds der Chemischen Industrie (FCI). This work was supported by the Deutsche Forschungsgemeinschaft (SFB 452) and the FCI. We thank Dr. Ingo Schnell for his involvement in the early part of this project, Dr. Kay Saalwächter for advice concerning the heteronuclear experiment, and Dr. Ulrich Burkert for his help during the synthesis of the complex.分子镊子主客体复合物的结构与动力学：耦合合成、固态核磁共振及量子化学计算 S.P.B. 感谢亚历山大·冯·洪堡基金会授予的研究奖学金。C.O. 感谢化学工业基金会（FCI）的利比希“教授资格”奖学金提供的资金支持。本研究得到了德国研究基金会（SFB 452）和 FCI 的支持。我们感谢英戈·施内尔博士参与本项目早期工作，感谢凯·萨尔瓦赫特博士在异核实验方面提供的建议，以及乌尔里希·布尔克特博士在复合物合成过程中给予的帮助。
Angew Chem Int Ed Engl. 2001 Feb 16;40(4):717-720.
6
"Nanoobjects" by Self-Assembly Concomitant with Modifications under Alterable Boundary Conditions: Incorporation of Paramagnetic Metal Centers (Cu(2+)) in Ring-Shaped Molybdenum-Oxide Based Clusters The authors thank Prof. D. Gatteschi, University of Florence (Italy), for helping with the interpretation of the ESR spectrum, and Dipl.-Chem. A. Berkle and Dr. J. Hockemeyer, University of Bielefeld (Germany), for their collaboration. C. R. thanks the Alexander von Humboldt Foundation for her fellowship. Financial support by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie is gratefully acknowledged.在可变边界条件下自组装并伴随修饰的“纳米物体”：在基于氧化钼的环状簇合物中引入顺磁性金属中心（Cu(2+)） 作者感谢意大利佛罗伦萨大学的D. Gatteschi教授在电子自旋共振光谱解释方面提供的帮助，以及德国比勒费尔德大学的化学硕士A. Berkle和J. Hockemeyer博士的合作。C. R.感谢亚历山大·冯·洪堡基金会授予她奖学金。作者衷心感谢德国研究基金会和化学工业基金会的资金支持。
Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4034-4037.
7
Oxidizing Polymers: A Polymer-Supported, Recyclable Hypervalent Iodine(V) Reagent for the Efficient Conversion of Alcohols, Carbonyl Compounds, and Unsaturated Carbamates in Solution J.R. gratefully acknowledges generous support from Prof. M. E. Maier, Tübingen, the Strukturfonds of the University of Tübingen, the Fonds der Chemischen Industrie, and the DFG. We thank Graeme Nicholson, Dietmar Schmid, and Daniel Bischoff for analytical support.
Angew Chem Int Ed Engl. 2001 Dec 3;40(23):4395-4397. doi: 10.1002/1521-3773(20011203)40:23<4395::aid-anie4395>3.0.co;2-r.
8
Supramolecular Nanocircles Consisting of Streptavidin and DNA This work was supported by the Deutsche Forschungsgemeinschaft (SPP 1072), the Fonds der Chemischen Industrie, and the Tönjes-Vagt Stiftung. We thank Prof. D. Blohm and Prof. H. Fuchs for generous support.
Angew Chem Int Ed Engl. 2000 Sep 1;39(17):3055-3059. doi: 10.1002/1521-3773(20000901)39:17<3055::aid-anie3055>3.0.co;2-r.
9
Resolution and Kinetic Stability of a Chiral Supramolecular Assembly Made of Labile Components Coordination Number Incommensurate Cluster Formation, Part 18. Financial support of this work was provided by NSF CHE-9709621 and by NSF and NATO-NSF exchange grants INT-9603212 and SRG 951516, respectively. We thank the Alexander-von-Humboldt Foundation for a Fellowship to A.T., and a Humboldt Research Award for Senior U.S. Scientists to K.R., and the Miller Foundation for a fellowship to M.Z. The authors gratefully acknowledge the assistance of Dr. F. J. Hollander and Dr. D. L. Caulder in selecting and mounting a suitable single crystal, and Prof. Julie A. Leary, Dr. Ulla N. Andersen, and J. J. Miranda for measuring mass spectra. Part 17: M. Ziegler, J. J. Miranda, U. N. Andersen, D. W. Johnson, J. A. Leary, K. N. Raymond, Angew. Chem., in press.由不稳定组分构成的手性超分子组装体的分辨率和动力学稳定性：配位数不匹配的簇形成，第18部分。本研究得到了美国国家科学基金会（NSF）CHE - 9709621项目以及NSF和北约 - NSF交流基金INT - 9603212和SRG 951516的资助。我们感谢亚历山大·冯·洪堡基金会授予A.T.的奖学金、授予K.R.的洪堡资深美国科学家研究奖，以及米勒基金会授予M.Z.的奖学金。作者们衷心感谢F. J. 霍兰德博士和D. L. 考尔德博士在挑选和安装合适单晶方面提供的帮助，以及朱莉·A. 利里教授、乌拉·N. 安德森博士和J. J. 米兰达在测量质谱方面提供的帮助。第17部分：M. 齐格勒、J. J. 米兰达、U. N. 安德森、D. W. 约翰逊、J. A. 利里、K. N. 雷蒙德，《德国应用化学》，即将发表。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):157-160.
10
Chaotropic Anions Strongly Stabilize Short, N-Capped Uncharged Peptide Helicies: A New Look at the Perchlorate Effect This research was supported by NIH GM 13453, by the NSF 9121702-CHE, by Pfizer Research, and by the award of a Feodor Lynen Fellowship from the Alexander von Humboldt-Stiftung to W.M.
Angew Chem Int Ed Engl. 2001 Oct 15;40(20):3819-3821.

引用本文的文献

1
Altering glycopeptide antibiotic biosynthesis through mutasynthesis allows incorporation of fluorinated phenylglycine residues.通过突变合成改变糖肽类抗生素的生物合成，能够掺入氟化苯甘氨酸残基。
RSC Chem Biol. 2024 Aug 12;5(10):1017-34. doi: 10.1039/d4cb00140k.
2
Atropopeptides are a Novel Family of Ribosomally Synthesized and Posttranslationally Modified Peptides with a Complex Molecular Shape.阿托肽是一类新型的核糖体合成和翻译后修饰的肽，具有复杂的分子形状。
Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202208361. doi: 10.1002/anie.202208361. Epub 2022 Sep 7.
3
Complex peptide natural products: Biosynthetic principles, challenges and opportunities for pathway engineering.
复杂肽类天然产物：生物合成原理、途径工程面临的挑战与机遇
Synth Syst Biotechnol. 2022 Feb 9;7(1):631-647. doi: 10.1016/j.synbio.2022.01.007. eCollection 2022 Mar.
4
Carrier Protein-Free Enzymatic Biaryl Coupling in Arylomycin A2 Assembly and Structure of the Cytochrome P450 AryC.无载体蛋白的酶促联芳基偶联在阿霉素 A2 组装中的应用及细胞色素 P450 AryC 的结构
Chemistry. 2022 Jan 10;28(2):e202103389. doi: 10.1002/chem.202103389. Epub 2021 Nov 26.
5
Mapping and Exploiting the Promiscuity of OxyB toward the Biocatalytic Production of Vancomycin Aglycone Variants.绘制并利用氧肟酸对生物催化生产万古霉素苷元变体的选择性。
ACS Catal. 2020 Aug 21;10(16):9287-9298. doi: 10.1021/acscatal.0c01719. Epub 2020 Jul 9.
6
Nonribosomal peptide synthetases and their biotechnological potential in Penicillium rubens.非核糖体肽合成酶及其在红青霉中的生物技术潜力。
J Ind Microbiol Biotechnol. 2021 Aug 24;48(7-8). doi: 10.1093/jimb/kuab045.
7
Secondary Metabolites of the Genus : Structures, Bioactivities and Biosynthesis.该属的次生代谢产物：结构、生物活性与生物合成
Molecules. 2021 Mar 26;26(7):1884. doi: 10.3390/molecules26071884.
8
Activation modes in biocatalytic radical cyclization reactions.生物催化自由基环化反应中的活化模式。
J Ind Microbiol Biotechnol. 2021 Jun 4;48(3-4). doi: 10.1093/jimb/kuab021.
9
PCR-based Screening Approach: A Rapid Method to Detect the Biosynthetic Potential of Antimicrobials in Actinobacterial Strains.基于 PCR 的筛选方法：一种快速检测放线菌菌株中抗生素生物合成潜力的方法。
Pol J Microbiol. 2020;69(2):1-11. doi: 10.33073/pjm-2020-016.
10
Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A.全合成揭示了小分子天然产物 tryptorubin A 中的非典型对映异构现象。
Science. 2020 Jan 24;367(6476):458-463. doi: 10.1126/science.aay9981. Epub 2020 Jan 2.