Thompson J C, Wilby G, Stough C
Brain Sciences Institute, Swinburne University, Hawthorn, Vic, Australia.
Hum Psychopharmacol. 2002 Apr;17(3):157-61. doi: 10.1002/hup.377.
The acute administration of nicotine via a cigarette has been demonstrated to enhance inspection time (IT), a measure of rapid visual information processing, while the nicotinic antagonist mecamylamine impairs IT. However, as transdermal nicotine patches provide a slow delivery of nicotine, it is unclear if they produce similar effects to nicotine administered by more rapid methods.
To examine the effects of transdermal nicotine on inspection time.
Ten moderate smokers were administered nicotine (21 mg/day) or placebo via a transdermal patch in a randomized, double-blind, repeated measures design. Subjects were administered the IT task at baseline, then 1, 3, and 6 h subsequent to patch application.
The change in IT from baseline was significantly different in the nicotine condition, relative to placebo, at 3 h but not 1 or 6 h.
The findings suggest that nicotine administered via transdermal patches improves IT, but this improvement may be subject to tolerance. Data from previous studies on tolerance to the cognitive effects of nicotine have been inconclusive. However, the slow delivery of nicotine from patches may be more likely to produce such effects.
通过香烟急性给予尼古丁已被证明可延长检查时间（IT），这是一种快速视觉信息处理的指标，而烟碱拮抗剂美加明会损害检查时间。然而，由于透皮尼古丁贴片提供的尼古丁释放缓慢，尚不清楚它们是否会产生与通过更快方法给予尼古丁类似的效果。
研究透皮尼古丁对检查时间的影响。
采用随机、双盲、重复测量设计，10名中度吸烟者通过透皮贴片给予尼古丁（21毫克/天）或安慰剂。在基线时对受试者进行检查时间任务测试，然后在贴片应用后1、3和6小时再次测试。
与安慰剂相比，尼古丁组在3小时时检查时间相对于基线的变化有显著差异，但在1小时和6小时时没有。
研究结果表明，通过透皮贴片给予尼古丁可改善检查时间，但这种改善可能会产生耐受性。先前关于尼古丁认知效应耐受性的研究数据尚无定论。然而，贴片缓慢释放尼古丁可能更易产生此类效果。
