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[中毒患者的临床和生物学监测]

[Clinical and biological surveillance of envenomed patients].

作者信息

Mion G, Olive F, Giraud D, Lambert E, Descraques C, Garrabé E, Goyffon M

机构信息

Service d'anesthésie-réanimation, Hôpital d'instruction des armées Bégin, Saint-Mandé, France.

出版信息

Bull Soc Pathol Exot. 2002 Aug;95(3):139-43.

Abstract

Faced with an envenomation, the problem is to take sufficiently rapidly the decision to administer the only effective treatment--immunotherapy--, to know which antivenom to choose and how long to administrate it. If the snake is not identified, symptoms and initial development give information on the type of venom. It is convenient to classify the symptoms according to four clinical types: i) the cobra syndrome with a potentially fatal evolution within two to ten hours and which resembles an Elapid bite, ii) the viper syndrome associating bleeding and inflammation, which can be due either to a viper, pit viper or, in Australia, to Elapids, iii) disturbance of blood circulating functions and iv) disturbance of other live functions. Between the third to the half of snakebite victims present no envenomation. Severe envenomations must be monitored in an intensive care unit, with experience in emergency management and monitoring of patients with major life-threatening conditions. Throughout the world, snakebites induce more than 100,000 deaths every year. Schematically, the emergency may be considered in terms of seconds for blood circulation disorders, minutes for respiratory paralysis, and hours for the coagulopathy.

摘要

面对蛇咬伤中毒情况,问题在于要足够迅速地决定采用唯一有效的治疗方法——免疫疗法,要知道选择哪种抗蛇毒血清以及使用多长时间。如果蛇的种类无法确定,症状和初期发展情况能提供有关毒液类型的信息。根据四种临床类型对症状进行分类很方便:i)眼镜蛇综合征,在两到十小时内有潜在致命风险,类似眼镜蛇科毒蛇咬伤;ii)蝰蛇综合征,伴有出血和炎症,可能由蝰蛇、蝮蛇引起,在澳大利亚也可能由眼镜蛇科毒蛇引起;iii)血液循环功能紊乱;iv)其他生命功能紊乱。三分之一到一半的蛇咬伤受害者没有出现中毒症状。严重中毒患者必须在重症监护病房进行监测,该病房要有处理重大危及生命情况患者的急诊管理和监测经验。在全球范围内,蛇咬伤每年导致超过10万人死亡。大致来说,血液循环障碍的紧急情况以秒计,呼吸麻痹以分钟计,凝血障碍以小时计。

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