Efimov A S, Slavnov V N, Sviatelik G V, Bezverkhaia T P, Buglak N I
Probl Endokrinol (Mosk). 1975 Mar-Apr;21(2):7-12.
On the basis of clinico-laboratory examination of 500 patients suffering from diabetes mellitus a comparison was made of the influence of treatment with insulin and sulfanilamides on disturbed metabolic processes promoting development of vascular affections. There were found no differences in the action of insulin and oral agents on the indices of lipid, protein and mucopolysaccharide metabolism and on activity of the enzymes of the pentose-phosphate cycle. Corticosteroid excretion normalized with the compensation of diabetes, irrespective of the type of the sugar-reducing preparations. A more pronounced increase in catecholamine excretion was seen in insulin therapy apparently in connection with greater variations in glycemia level. A conclusion was drawn on analogous effect of insulin and sulphanilamides on the metabolic changes under study in diabetes. In difference from the action of insulin, a marked allergization of the of the organism accompanying the action of sulphanilamides, and their normalizing effect on the vascular permeability should be referred to the positive aspects of sulphanilamide action.
在对500例糖尿病患者进行临床实验室检查的基础上，比较了胰岛素和磺胺类药物治疗对促进血管病变发展的代谢紊乱过程的影响。发现胰岛素和口服药物对脂质、蛋白质和粘多糖代谢指标以及磷酸戊糖循环酶活性的作用没有差异。无论降糖制剂的类型如何，随着糖尿病的代偿，皮质类固醇排泄恢复正常。胰岛素治疗中儿茶酚胺排泄的增加更为明显，这显然与血糖水平的更大波动有关。得出了胰岛素和磺胺类药物对糖尿病中所研究的代谢变化具有类似作用的结论。与胰岛素的作用不同，磺胺类药物作用伴随的机体明显过敏反应以及它们对血管通透性的正常化作用应被视为磺胺类药物作用的积极方面。
