Cattell Emma, Kelly Charles, Middleton Mark R
Cancer Research UK Medical Oncology Unit, Churchill Hospital, Oxford, UK.
Semin Oncol. 2002 Oct;29(5):513-7. doi: 10.1053/sonc.2002.35246.
CNS involvement is a common feature of metastatic melanoma. Despite this, there is little evidence upon which clinicians can base decisions about treatment. The short prognosis and significant symptoms usually associated with melanoma brain metastases have excluded these patients from clinical trials. In Europe the standard treatment involves whole brain radiotherapy, although selected centers offer other modalities, including surgery, radiosurgery, and chemotherapy.
中枢神经系统受累是转移性黑色素瘤的常见特征。尽管如此，临床医生几乎没有证据可用于做出治疗决策。黑色素瘤脑转移通常伴随的预后不良和严重症状使这些患者被排除在临床试验之外。在欧洲，标准治疗方法包括全脑放疗，不过部分中心提供其他治疗方式，包括手术、放射外科和化疗。
