Regoli F, Gorbi S, Frenzilli G, Nigro M, Corsi I, Focardi S, Winston G W
Istituto di Biologia e Genetica, Università di Ancona, Italy.
Mar Environ Res. 2002 Sep-Dec;54(3-5):419-23. doi: 10.1016/s0141-1136(02)00146-0.
An integrate approach will be discussed for investigations on oxidative stress in xenobiotic toxicity. While the analysis of individual antioxidants is useful for their sensitivity and to understand the mode of action of a stressor, the integration with the analysis of the total antioxidant capacity provides a more holistic assessment of the overall biological significance of such variations. TOSC has a greater predictive value on the health condition of the organisms and allows to discriminate the different role of specific ROS in oxidative stress syndrome.
将讨论一种用于研究异生物素毒性中氧化应激的综合方法。虽然对单个抗氧化剂的分析对于了解其敏感性以及应激源的作用模式很有用，但将其与总抗氧化能力的分析相结合，可以更全面地评估此类变化的整体生物学意义。总氧清除能力（TOSC）对生物体的健康状况具有更大的预测价值，并有助于区分特定活性氧在氧化应激综合征中的不同作用。
