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使用人和犰狳抗原对麻风病人进行费尔南德斯反应和光田反应的比较。一项双盲研究。

Comparison in leprosy patients of Fernandex and Mitsuda reactions using human and armadillo antigens. A double-blind study.

作者信息

Millar J W, Gannon C, Chan C S

出版信息

Int J Lepr Other Mycobact Dis. 1975 Jul-Sep;43(3):226-33.

PMID:1240871
Abstract

The Mitsuda and Fernandez reactions to bacilli prepared from lesions of human patients and bacilli from infected armadillos were studied in 112 leprosy patients. It was observed that there is no substantial difference when armadillo lepromin is used instead of human lepromin except that a larger induration occurs with the use of the armadillo lepromin in a majority of cases. The number of those reporting a burning sensation at the armadillo lepromin injection site was slightly higher in lepromatous patients; whereas the burning sensation was observed at the human lepromin injection site by the tuberculoid cases. With the significant information compiled in this study, it is concluded that lepromin prepared from bacilli obtained from infected armadillos is as effective as that prepared from bacilli obtained from the lesions of leprosy patients.

摘要

在112例麻风病患者中研究了对从人类患者病变处制备的杆菌以及感染犰狳的杆菌的光田反应和费尔南德斯反应。观察到,使用犰狳麻风菌素代替人麻风菌素时没有实质性差异,只是在大多数情况下使用犰狳麻风菌素会出现更大的硬结。在瘤型患者中,报告在犰狳麻风菌素注射部位有烧灼感的人数略多;而结核样型病例在人麻风菌素注射部位观察到有烧灼感。根据本研究汇编的重要信息,得出结论:从感染犰狳获得的杆菌制备的麻风菌素与从麻风病患者病变处获得的杆菌制备的麻风菌素一样有效。

相似文献

1
Comparison in leprosy patients of Fernandex and Mitsuda reactions using human and armadillo antigens. A double-blind study.使用人和犰狳抗原对麻风病人进行费尔南德斯反应和光田反应的比较。一项双盲研究。
Int J Lepr Other Mycobact Dis. 1975 Jul-Sep;43(3):226-33.
2
Specificity of the 48-hour reaction to Mitsuda antigen. Use of a soluble antigen from human and armadillo lepromin.对光田抗原48小时反应的特异性。人麻风菌素和犰狳麻风菌素可溶性抗原的应用。
Bull World Health Organ. 1975;52(2):187-91.
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Comparative study of Mitsuda reaction to nude mouse and armadillo lepromin preparations using nine-banded armadillos.使用九带犰狳对裸鼠和犰狳麻风菌素制剂的光田反应的比较研究。
Int J Lepr Other Mycobact Dis. 2000 Mar;68(1):18-22.
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[Correlation between early (Fernandez) and late (Mitsuda) reactions in non-contact children and adolescents without manifestations of leprosy, tested with human lepromin and different concentrations of armadillo antigen in 3 double-blind trials].[在3项双盲试验中,对无麻风表现的非接触儿童和青少年进行人麻风菌素及不同浓度犰狳抗原检测后,早期(费尔南德斯反应)与晚期(光田反应)反应之间的相关性]
Acta Leprol. 1982 Jan-Jun(86-87):97-109.
5
Comparison of reactions to human and armadillo lepromins in leprosy.麻风病中对人麻风菌素和犰狳麻风菌素反应的比较。
Int J Lepr Other Mycobact Dis. 1975 Jul-Sep;43(3):218-25.
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Double blind trials to determine the late reactivity of leprosy patients and unaffected persons to different concentrations of armadillo lepromin in comparison to human lepromin.双盲试验旨在确定麻风病人和未感染者对不同浓度犰狳麻风菌素相对于人麻风菌素的迟发性反应。
Int J Lepr Other Mycobact Dis. 1980 Jun;48(2):126-34.
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Immunological changes observed in indeterminate and lepromatous leprosy patients and Mitsuda-negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG.在接种麻风分枝杆菌和卡介苗混合物后,在未定类麻风患者、瘤型麻风患者及 Mitsuda 反应阴性的接触者中观察到的免疫学变化。
Clin Exp Immunol. 1979 May;36(2):214-20.
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Prevalence and significance of positive Mitsuda reaction in the nine-banded armadillo (Dasypus novemcinctus).九带犰狳(Dasypus novemcinctus)中 Mitsuda 反应阳性的患病率及意义。
Int J Lepr Other Mycobact Dis. 1987 Dec;55(4):685-8.
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Effect of repeated lepromin testing on experimental nine-banded armadillo leprosy.重复麻风菌素试验对实验性九带犰狳麻风病的影响。
Indian J Lepr. 1985 Oct-Dec;57(4):716-27.
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A comparative study on the Mitsuda type response to antigens of chemoautotrophic nocardioform bacteria and to standard lepromin in leprosy patients.
Acta Leprol. 1999;11(3):105-12.

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