Jones Michael R, Fyfe Paul K, Roszak Aleksander W, Isaacs Neil W, Cogdell Richard J
Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK.
Biochim Biophys Acta. 2002 Oct 11;1565(2):206-14. doi: 10.1016/s0005-2736(02)00570-9.
The purple bacterial reaction centre uses the energy of sunlight to power energy-requiring reactions such as the synthesis of ATP. During the last 20 years, a combination of X-ray crystallography, spectroscopy and mutagenesis has provided a detailed insight into the mechanism of light energy transduction in the bacterial reaction centre. In recent years, structural techniques including X-ray crystallography and neutron scattering have also been used to examine the environment of the reaction centre. This mini-review focuses on recent studies of the surface of the reaction centre, and briefly discusses the importance of the specific protein-lipid interactions that have been resolved for integral membrane proteins.
紫色细菌反应中心利用太阳光的能量来驱动诸如ATP合成等需要能量的反应。在过去20年里,X射线晶体学、光谱学和诱变技术相结合,让人深入了解了细菌反应中心光能转导的机制。近年来,包括X射线晶体学和中子散射在内的结构技术也被用于研究反应中心的环境。这篇小型综述聚焦于反应中心表面的近期研究,并简要讨论了已解析的膜内在蛋白特定蛋白质-脂质相互作用的重要性。