Yagupsky Pablo, Peled Nechama, Katz Orna
Clinical Microbiology Laboratory, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
J Clin Microbiol. 2002 Nov;40(11):4180-4. doi: 10.1128/JCM.40.11.4180-4184.2002.
The age, sex, and seasonal distributions of invasive Kingella kingae infections in southern Israel were examined and compared to the epidemiology of respiratory carriage of the organism. Medical records of all patients diagnosed between 1988 and 2002 were reviewed, and 2,044 oropharyngeal specimens were cultured on selective media during two periods (February to May and October to December) in 2001. Invasive infections significantly affected children (73 of 74 patients [98.6%] were younger than 4 years), 50 patients (67.8%) were males (P = 0.045), and 55 episodes (74.3%) occurred between July and December (P = 0.004). Carriage was higher in the 0- to 3-year-old group and decreased with increasing age (P for trend = 0.0008). Carriage rates were similar in both sexes and did not significantly differ between the February-to-May and October-to-December periods. The highest rate of carriage of K. kingae coincided with the age (less than 4 years) at which invasive infections were especially frequent. The peculiar sex and seasonal distributions of invasive disease, however, cannot be readily explained by the epidemiology of respiratory carriage. Viral infections and other yet-to-be-defined cofactors may play a role in the causation of invasive K. kingae infections.
对以色列南部侵袭性金氏金杆菌感染的年龄、性别和季节分布进行了研究，并与该菌呼吸道携带的流行病学情况进行了比较。回顾了1988年至2002年间所有确诊患者的病历，并于2001年的两个时间段（2月至5月和10月至12月）在选择性培养基上培养了2044份口咽标本。侵袭性感染主要影响儿童（74例患者中有73例[98.6%]年龄小于4岁），50例患者（67.8%）为男性（P = 0.045），55例感染事件（74.3%）发生在7月至12月之间（P = 0.004）。携带率在0至3岁年龄组中较高，并随年龄增长而下降（趋势P值 = 0.0008）。两性的携带率相似，2月至5月和10月至12月期间之间无显著差异。金氏金杆菌的最高携带率与侵袭性感染特别常见的年龄（小于4岁）相吻合。然而，侵袭性疾病独特的性别和季节分布不能通过呼吸道携带的流行病学情况轻易解释。病毒感染和其他尚未明确的辅助因素可能在侵袭性金氏金杆菌感染的病因中起作用。
