有机溶剂与多发性硬化症风险
Organic solvents and the risk of multiple sclerosis.
作者信息
Riise Trond, Moen Bente E, Kyvik Knut Rasmus
机构信息
Section for Occupational Medicine, Department of Public Health, University of Bergen, Norway.
出版信息
Epidemiology. 2002 Nov;13(6):718-20. doi: 10.1097/00001648-200211000-00018.
BACKGROUND
Epidemiologic studies suggest that environmental factors may be part of the yet unknown causation of multiple sclerosis (MS). Several case-control studies have shown a history of elevated exposure to organic solvents among cases.
METHODS
Three cohorts of 11,542 painters, 36,899 construction workers and 9,314 food-processing workers were identified by the 1970 census in Norway. The cohorts were followed until the end of 1986 for registration of disability pensions.
RESULTS
A total of nine painters, 12 construction workers and six food workers had received a disability pension because of MS. The relative risk for painters compared with workers not exposed to organic solvents was 2.0 (95% confidence inter-val = 0.9-4.5) for MS.
CONCLUSIONS
These results are compatible with the hypothesis of organic solvents being a possible risk factor for MS.
背景
流行病学研究表明，环境因素可能是多发性硬化症（MS）尚未明确的病因的一部分。多项病例对照研究显示，病例中有有机溶剂暴露增加的病史。
方法
通过挪威1970年人口普查确定了三组队列，分别为11,542名油漆工、36,899名建筑工人和9,314名食品加工工人。对这些队列进行随访，直至1986年底，记录残疾抚恤金情况。
结果
共有9名油漆工、12名建筑工人和6名食品工人因MS领取了残疾抚恤金。与未接触有机溶剂的工人相比，油漆工患MS的相对风险为2.0（95%置信区间=0.9 - 4.5）。
结论
这些结果与有机溶剂可能是MS风险因素的假设相符。
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