Department of Pharmacology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
BMJ Open. 2013 Jun 20;3(6):e002894. doi: 10.1136/bmjopen-2013-002894.
The aim of this study was to estimate the occupational risks in relation to multiple sclerosis (MS). The immediate background for this research was our finding that there had been a high number of critical illness insurance claims by patients diagnosed with MS within the agricultural segment of a Danish pension fund.
An open insurance cohort. All payouts for the critical illness insurance from 2002 to 2011 were continuously registered.
PensionDanmark; one of Denmark's largest pension funds.
PensionDanmark insures more than 300 000 members of the Danish Confederation of Trade Unions against critical illness. All members are insured, and all policies are identical. The total exposure is 3.3 million person-years.
The incidence of MS.
During the 10-year period, 389 persons were diagnosed with MS. The crude incidence rate for men was 10.2/100 000; the corresponding figure for women was 16.1/100 000. We found signs of an overall effect of occupation on the risk of developing MS, and the high frequency found within the agricultural segment was attributed to dairy operators, who had an incidence of MS 2.0 times higher than the rest of the study's population (95% CI=1.2 to 3.0).
Our results indicate some occupational risk factors in MS, and this should be investigated further.
本研究旨在评估与多发性硬化症（MS）相关的职业风险。这项研究的直接背景是我们发现，在丹麦一家养老金基金的农业部门，被诊断患有 MS 的患者的重大疾病保险索赔数量很高。
开放式保险队列。从 2002 年到 2011 年，所有重大疾病保险的理赔都在持续登记。
PensionDanmark；丹麦最大的养老金基金之一。
PensionDanmark 为丹麦工会联合会的 30 多万名成员提供重大疾病保险。所有成员都投保，所有政策都是相同的。总风险暴露为 330 万人年。
MS 的发病率。
在 10 年期间，有 389 人被诊断患有 MS。男性的粗发病率为 10.2/100000；女性的相应数字为 16.1/100000。我们发现职业对 MS 发病风险存在总体影响的迹象，而农业部门的高发病率归因于乳牛饲养员，他们的 MS 发病率比研究人群的其他人群高 2 倍（95%CI=1.2 至 3.0）。
我们的结果表明 MS 存在一些职业风险因素，这应该进一步调查。
