Udell Ira J, Guidera Ann C, Madani-Becker Julie
Department of Ophthalmology, Long Island Jewish Medical Center, Great Neck, New York, USA.
Cornea. 2002 Nov;21(8):778-80. doi: 10.1097/00003226-200211000-00009.
To report the effect of topically applied ketotifen fumarate in the treatment of superior limbic keratoconjunctivitis (SLK).
Five patients with clinical findings of bilateral SLK with no relief of symptoms with standard reported modalities of treatment were treated with topical ketotifen fumarate twice daily in both eyes. All patients were evaluated 2 to 4 weeks after initiation of treatment of symptomatic and clinical improvement and at regular intervals thereafter.
Topical ketotifen provided immediate relief of ocular symptoms in all patients. In one patient, the response was long lasting, whereas in the other four, it was temporary, lasting 1 to 3 months. The objective signs, however, did not necessarily correlate with the subjective improvement.
Ketotifen fumarate can be effective at least in the short to medium term in the management of SLK. Although the mechanism of action of ketotifen remains unclear, this preliminary experience further supports the use of agents with mast cell-stabilizing activity in the treatment of SLK.
报告局部应用富马酸酮替芬治疗上睑缘角结膜炎（SLK）的效果。
5例双侧SLK患者，采用标准报道的治疗方法症状未缓解，双眼每日两次局部应用富马酸酮替芬进行治疗。在开始治疗后2至4周对所有患者进行症状和临床改善评估，并在此后定期评估。
局部应用酮替芬使所有患者的眼部症状立即得到缓解。1例患者的反应持续时间长，而其他4例为暂时性，持续1至3个月。然而，客观体征不一定与主观改善相关。
富马酸酮替芬至少在短期至中期对SLK的治疗有效。尽管酮替芬的作用机制尚不清楚，但这一初步经验进一步支持使用具有肥大细胞稳定活性的药物治疗SLK。
