Artal M N, Luna J D, Discepola M
Fundación VER Casilla de Correo, Córdoba, Argentina.
Acta Ophthalmol Scand Suppl. 2000(230):64-5. doi: 10.1034/j.1600-0420.2000.078s230064.x.
To compare the ocular comfort of two ophthalmic anti-allergic agents: olopatadine hydrochloride 0.1% and ketotifen fumarate 0.05%.
In a double-masked, multi-centered, randomized trial, 80 subjects were asked to make a 'forced choice' based on ocular comfort between one drop of olopatadine hydrochloride 0.1% instilled in one eye and one drop of ketotifen fumarate 0.05% instilled in the contralateral eye. At one site, the incidence of adverse reactions was also reported.
All subjects (100%) selected olopatadine as the more comfortable formulation. One site (n = 35) reported a 49% incidence of moderate burning and a 49% incidence of mild burning after ketotifen instillation. One subject (2% of population) at this site experienced no ocular discomfort with ketotifen. There were no reports of discomfort associated with olopatadine instillation.
Olopatadine is a more comfortable ophthalmic preparation than ketotifen.
比较两种眼科抗过敏药物：0.1%盐酸奥洛他定和0.05%富马酸酮替芬的眼部舒适度。
在一项双盲、多中心、随机试验中，80名受试者被要求根据眼部舒适度，在一只眼滴入一滴0.1%盐酸奥洛他定与对侧眼滴入一滴0.05%富马酸酮替芬之间做出“强制选择”。在一个研究点，还报告了不良反应的发生率。
所有受试者（100%）均选择奥洛他定作为更舒适的制剂。一个研究点（n = 35）报告，滴入酮替芬后，中度灼烧的发生率为49%，轻度灼烧的发生率为49%。该研究点有一名受试者（占总人数的2%）使用酮替芬后未出现眼部不适。没有关于滴入奥洛他定后出现不适的报告。
与酮替芬相比，奥洛他定是一种更舒适的眼科制剂。
