使用自体血清治疗复发性角膜糜烂
Treatment of recurrent corneal erosions using autologous serum.
作者信息
del Castillo Jose Manuel Benítez, de la Casa Jose Maria Martínez, Sardiña Ricardo Cuiña, Fernández Rosalia Méndez, Feijoo Julian García, Gómez Alfredo Castillo, Rodero Maria Matilla, Sánchez Julian García
机构信息
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Hospital Clínico San Carlos, Madrid, Spain.
出版信息
Cornea. 2002 Nov;21(8):781-3. doi: 10.1097/00003226-200211000-00010.
PURPOSE
To study the effect of autologous serum in the treatment of recurrent corneal erosions.
METHODS
Eleven eyes of 11 consecutive patients with acute macroform corneal erosions who had suffered several relapses despite receiving different types of treatment were analyzed from November 2000 to February 2002. All patients were treated with autologous serum for 3 months.
RESULTS
Mean follow-up time was 9.4 +/- 3.7 months (range, 4-16). No side effects were noted in any of the treated patients. Treatments prior to the use of autologous serum had failed to avoid recurrences in all the patients, with the mean recurrence rate being 2.2 recurrences per month of follow-up. After the onset of serum treatment, only a single recurrence was recorded in three of the patients (0.028 recurrences per month of follow-up).
CONCLUSION
The use of autologous serum for the treatment of patients with recurrent corneal erosion is effective and safe in reducing the number of recurrences experienced by patients.
目的
研究自体血清在复发性角膜糜烂治疗中的作用。
方法
分析2000年11月至2002年2月期间连续11例急性大疱性角膜糜烂患者的11只眼睛，这些患者尽管接受了不同类型的治疗仍多次复发。所有患者均接受自体血清治疗3个月。
结果
平均随访时间为9.4±3.7个月（范围4 - 16个月）。所有接受治疗的患者均未出现副作用。在使用自体血清治疗之前，所有患者的治疗均未能避免复发，平均复发率为随访期间每月2.2次复发。血清治疗开始后，仅3例患者出现1次复发（随访期间每月0.028次复发）。
结论
使用自体血清治疗复发性角膜糜烂患者在减少患者复发次数方面是有效且安全的。
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