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复发性角膜糜烂患者角膜上皮中基质金属蛋白酶-2和基质金属蛋白酶-3浓度升高。

Increased Matrix Metalloproteinase-2 and Matrix Metalloproteinase-3 Concentrations in Corneal Epithelium of Patients with Recurrent Corneal Erosions.

作者信息

Jadczyk-Sorek Katarzyna, Garczorz Wojciech, Bubała-Stachowicz Beata, Francuz Tomasz, Mrukwa-Kominek Ewa

机构信息

Department of Ophthalmology, Gibiński University Clinical Center, Medical University of Silesia, Katowice 40-514, Poland.

Department of Biochemistry, Faculty of Medical Sciences, Katowice, Medical University of Silesia, Katowice 40-027, Poland.

出版信息

J Ophthalmol. 2022 Sep 25;2022:5024037. doi: 10.1155/2022/5024037. eCollection 2022.

DOI:10.1155/2022/5024037
PMID:36199293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9527436/
Abstract

PURPOSE

To assess the role of selected matrix metalloproteinases in defective corneal re-epithelization in patients with recurrent corneal erosions.

SUBJECTS

The study group (group 1) included patients with recurrent corneal erosions qualified for phototherapeutic keratectomy. The group 1 was divided into two subgroups regarding the etiology of recurrent corneal erosions: group 1A, Cogan's basement membrane dystrophy, and group 1B, trauma. The control group (group 2) included patients with healthy eyes qualified for Epi-Bowman Keratectomy.

METHODS

The analyzed material was the corneal epithelium collected during phototherapeutic keratectomy or Epi-Bowman Keratectomy in the study or control group, respectively. Matrix metalloproteinases concentration was determined by an immunohistochemical method using Human Magnetic Luminex® Assay.

RESULTS

The study revealed a statistically significantly higher concentration of matrix metalloproteinase-2 in group 1 compared to the control and a statistically significantly higher concentration of matrix metalloproteinase-3 in group 1 compared to the control.

CONCLUSIONS

The results obtained in the study can prove that matrix metalloproteinase-2 and matrix metalloproteinase-3 having the ability to dissolve anchoring fibers and the corneal epithelial basement membrane could be responsible for epithelial instability and their accumulation in the corneal epithelium may induce recurrence of erosion.

摘要

目的

评估特定基质金属蛋白酶在复发性角膜糜烂患者角膜上皮修复缺陷中的作用。

研究对象

研究组（第1组）包括符合光治疗性角膜切削术条件的复发性角膜糜烂患者。根据复发性角膜糜烂的病因，第1组又分为两个亚组：1A组，科根角膜上皮基底膜营养不良；1B组，外伤。对照组（第2组）包括符合上皮-前弹力层角膜切除术条件的健康眼患者。

方法

分析的材料分别是研究组或对照组在光治疗性角膜切削术或上皮-前弹力层角膜切除术中采集的角膜上皮。采用人磁性Luminex®检测法通过免疫组织化学方法测定基质金属蛋白酶浓度。

结果

研究显示，与对照组相比，第1组中基质金属蛋白酶-2的浓度在统计学上显著更高，且与对照组相比，第1组中基质金属蛋白酶-3的浓度在统计学上显著更高。

结论

该研究获得的结果可以证明，具有溶解锚定纤维和角膜上皮基底膜能力的基质金属蛋白酶-2和基质金属蛋白酶-3可能导致上皮不稳定，并且它们在角膜上皮中的积聚可能诱发糜烂复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11bb/9527436/affa73ca880e/JOPH2022-5024037.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11bb/9527436/52a9f65830a2/JOPH2022-5024037.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11bb/9527436/9c3e99d56469/JOPH2022-5024037.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11bb/9527436/7bbcdd1258a7/JOPH2022-5024037.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11bb/9527436/70d50da5cfc5/JOPH2022-5024037.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11bb/9527436/affa73ca880e/JOPH2022-5024037.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11bb/9527436/52a9f65830a2/JOPH2022-5024037.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11bb/9527436/9c3e99d56469/JOPH2022-5024037.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11bb/9527436/7bbcdd1258a7/JOPH2022-5024037.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11bb/9527436/70d50da5cfc5/JOPH2022-5024037.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11bb/9527436/affa73ca880e/JOPH2022-5024037.005.jpg

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Phototherapeutic keratectomy.光疗性角膜切除术。
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