Scardino Mary Keirnan, Hwang Shih-Jen, Hanna Christopher L, Danneffel-Mandelkorn Mary Beth, Wilhelmus Kirk R
Lions Eye Bank of Texas, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA.
Cornea. 2002 Nov;21(8):798-802. doi: 10.1097/00003226-200211000-00014.
To assess the reproducibility of relatives' replies to questions asked at the time of corneal donation and again 2 months later concerning infectious disease risk factors and to identify characteristics associated with inconsistent responses.
A reinterview study involving individuals who answered questions regarding an eye donor's sociomedical history within 1 day of the decedent's death and who consented to be recontacted 6 to 12 weeks later. The main outcome measures were frequency of answering differently on the same questions of infectious disease risk factors and the donors' and relatives' characteristics that predicted inconsistency.
Of 368 individuals who agreed to a reinterview, 263 (71.5%) completed and returned the survey questionnaire. Thirty-eight (14.4%) respondents answered differently on at least one question concerning infectious disease risk factors. The family of donors with a trauma-related death was 2.9 [95% confidence interval (CI), 1.0-8.3] times more likely to give inconsistent responses. Different responses to behavioral questions occurred 22 (95% CI, 1.6-315) times more often by relatives of donors who were both younger than 40 years old and had a tattoo.
The postmortem sociomedical interview cannot assure complete knowledge of the risk of potentially transmissible disease of all donors. Relatives of young, tattooed donors tend to give inconsistent responses about infectious disease risk factors.
评估亲属在角膜捐献时及2个月后对有关传染病危险因素问题的回答的可重复性,并确定与回答不一致相关的特征。
一项重新访谈研究,涉及在死者死亡1天内回答有关眼捐献者社会医学史问题且同意在6至12周后再次被联系的个体。主要结局指标是对传染病危险因素相同问题回答不同的频率以及预测不一致性的捐献者和亲属的特征。
在368名同意重新访谈的个体中,263名(71.5%)完成并返回了调查问卷。38名(14.4%)受访者对至少一个有关传染病危险因素的问题回答不同。因创伤相关死亡的捐献者家属给出不一致回答的可能性高2.9倍[95%置信区间(CI),1.0 - 8.3]。年龄小于40岁且有纹身的捐献者的亲属对行为问题给出不同回答的情况发生频率高22倍(95% CI,1.6 - 315)。
死后社会医学访谈不能确保完全了解所有捐献者潜在可传播疾病的风险。年轻且有纹身的捐献者的亲属在传染病危险因素方面往往给出不一致的回答。