Micheli Federico, Scorticati María Clara, Raina Gabriela
Programa de Parkinson y Movimientos Anormales, Instituto de Neurociencias, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina.
Clin Neuropharmacol. 2002 Sep-Oct;25(5):260-2. doi: 10.1097/00002826-200209000-00006.
Botulinum toxin is a well-known therapy for patients with diverse movement disorders. Its application has been extended to other disorders. Here, we document the case of a 70-year-old man with hemifacial spasm associated to trigeminal neuralgia secondary to an ectatic basilar artery. He was treated with botulinum toxin type A, 2.5 mouse units over five sites at the orbicularis oculi and one over the buccinator muscle. After botulinum toxin injections, relief was gained not only from twitching but also from pain. When the effects of the toxin vanished, spasms and pain recurred. Further infiltrations were given every 12 weeks following the same response pattern. This observation further validates the increasing role of botulinum toxin in pain management.
肉毒杆菌毒素是治疗各种运动障碍患者的一种知名疗法。其应用已扩展到其他疾病。在此,我们记录了一名70岁男性的病例,该患者患有与扩张性基底动脉继发的三叉神经痛相关的半面痉挛。他接受了A型肉毒杆菌毒素治疗,在眼轮匝肌的五个部位注射了2.5个鼠单位,在颊肌注射了1个鼠单位。注射肉毒杆菌毒素后,不仅抽搐得到缓解,疼痛也有所减轻。当毒素的作用消失后,痉挛和疼痛再次出现。按照相同的反应模式,每12周进行一次进一步的注射。这一观察结果进一步证实了肉毒杆菌毒素在疼痛管理中日益重要的作用。