锌强化口服补液盐对6至35个月急性腹泻儿童的疗效。

Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea.

作者信息

Bahl Rajiv, Bhandari Nita, Saksena Manju, Strand Tor, Kumar Geeta T, Bhan Maharaj K, Sommerfelt Halvor

机构信息

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

出版信息

J Pediatr. 2002 Nov;141(5):677-82. doi: 10.1067/mpd.2002.128543.

DOI:10.1067/mpd.2002.128543

PMID:12410197

Abstract

OBJECTIVE

To determine the efficacy of zinc-fortified oral rehydration salts solution (ORS) in comparison to ORS without zinc in 6- to 35-month-old urban children with acute diarrhea not sick enough to be hospitalized.

DESIGN

Double-blind, randomized, controlled trial.

METHODS

Children (n = 1219) with acute diarrhea were randomly assigned to one of 3 groups. The first group received a zinc syrup (15 mg zinc to 6- to 11-month-old children and 30 mg to 12- to 35-month-old children), the second group received zinc premixed with ORS (40 mg/L), and the control children received ORS only. Households were visited twice weekly until recovery.

RESULTS

The total number of stools was lower in the zinc-ORS group (rate ratio, 0.83; 95% CI, 0.71-0.96), as was the proportion of children with watery stools (odds ratio, 0.61; 95% CI, 0.39-0.95), compared with the control group; there was no significant effect on diarrheal duration. ORS intake and proportion of children with vomiting were not significantly different between the zinc-ORS and control groups. The zinc syrup group had lower diarrheal duration (relative hazards, 0.89; 95% CI, 0.80-0.99) and total stools (rate ratio, 0.73; 95% CI, 0.70-0.77) than control children.

CONCLUSIONS

Zinc-ORS was moderately efficacious in reducing the severity of acute diarrhea without increasing vomiting or reducing ORS intake.

摘要

目的

比较含锌口服补液盐溶液（ORS）与不含锌的ORS对6至35个月大、病情尚不足以住院的城市急性腹泻儿童的疗效。

设计

双盲、随机、对照试验。

方法

1219名急性腹泻儿童被随机分为3组。第一组接受锌糖浆（6至11个月大儿童服用15毫克锌，12至35个月大儿童服用30毫克锌），第二组接受与ORS预混合的锌（40毫克/升），对照组儿童仅接受ORS。每周对家庭进行两次访视，直至康复。

结果

与对照组相比，含锌ORS组的粪便总数较低（率比为0.83；95%可信区间为0.71至0.96），水样便儿童的比例也较低（优势比为0.61；95%可信区间为0.39至0.95）；对腹泻持续时间无显著影响。含锌ORS组与对照组之间的ORS摄入量和呕吐儿童比例无显著差异。锌糖浆组的腹泻持续时间（相对风险为0.89；95%可信区间为0.80至0.99）和粪便总数（率比为0.73；95%可信区间为0.70至0.77）均低于对照组儿童。