Eskander Ayman E, Sherif Lobna S, Nabih Mohammad, Baroudy Nevine R El, Marcos Ghobrial C, Badawy Ehsan A, Refay Amira S El
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Child Health, National Research Centre, Cairo, Egypt.
Open Access Maced J Med Sci. 2017 Aug 12;5(5):677-680. doi: 10.3889/oamjms.2017.097. eCollection 2017 Aug 15.
Diarrhea remains the most common infectious disease worldwide. Zinc has been studied extensively recently for its potential effect on prevention, control and treatment of acute diarrhoea.
This study was designed to correlate the level of zinc with the severity of pediatric diarrhoea estimated by Vesikari Scoring System.
The present study included 80 children aged two months to 30 months from those suffering from the acute diarrheal episode and admitted to Pediatric Hospital "Abo El Rish" Cairo University. Serum Zinc level was assessed by a colorimetric method with a spectrophotometer.
Zinc deficiency was detected in 45 (56.2%) patient of the studied group Significant negative correlations were found between serum zinc level and severity of dehydration and duration of hospitalization (p < 0.05).
Zinc level has an essential role in acute pediatric diarrhoea. Zinc therapy should be considered beside Oral rehydration salts (ORS) to achieve maximum impact on diarrheal diseases; clinical trials are recommended to support the zinc supplementation in developing countries.
腹泻仍然是全球最常见的传染病。锌最近因其对急性腹泻的预防、控制和治疗的潜在作用而受到广泛研究。
本研究旨在将锌水平与通过韦西卡里评分系统评估的小儿腹泻严重程度相关联。
本研究纳入了开罗大学“阿卜杜勒·里什”儿童医院收治的80名年龄在2个月至30个月之间患有急性腹泻的儿童。采用分光光度计比色法评估血清锌水平。
研究组45例(56.2%)患者检测到锌缺乏。血清锌水平与脱水严重程度和住院时间之间存在显著负相关(p<0.05)。
锌水平在小儿急性腹泻中起重要作用。除口服补液盐(ORS)外,应考虑锌治疗,以对腹泻疾病产生最大影响;建议进行临床试验以支持发展中国家的锌补充。