Leung Alexander Kc, Hon Kam Lun
Department of Pediatrics, University of Calgary, and Alberta Children's Hospital, Calgary, Alberta, Canada.
Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Drugs Context. 2021 Mar 26;10. doi: 10.7573/dic.2020-11-7. eCollection 2021.
Viral gastroenteritis is the most common diarrhoeal disorder seen in general practice and emergency departments. This article aims to provide a narrative updated review on the evaluation and management of viral gastroenteritis in children.
A PubMed search was performed with Clinical Queries using the key term 'viral gastroenteritis'. The search strategy included clinical trials, meta-analyses, randomized controlled trials, observational studies and reviews. The search was restricted to the English literature and the paediatric population.
Acute viral gastroenteritis is usually self-limiting. However, it can lead to dehydration and electrolyte imbalance if not properly treated. Adequate fluids containing physiological concentrations of glucose and electrolytes should be provided to compensate for gastrointestinal losses and cover maintenance needs. Oral rehydration therapy is as effective as intravenous (IV) fluid therapy for rehydration for children with mild-to-moderate dehydration. Measurements of serum electrolytes, creatinine and glucose are usually not necessary and should only be considered in a subset of children with severe dehydration who require hospitalization and IV therapy. Judicious use of ondansetron can increase the success rate of oral rehydration therapy and minimize the need for IV therapy and hospitalization.
Acute viral gastroenteritis is associated with substantial morbidity in developed countries and significant mortality in developing countries. Physicians should educate caregivers on proper personal hygiene and handwashing to prevent faecal to oral transmission of the pathogen as well as the importance of rotavirus vaccine in the prevention of rotavirus gastroenteritis. Several norovirus vaccines are currently undergoing clinical trials with promising results. It is hoped that development of an effective norovirus vaccine will further reduce the incidence of viral gastroenteritis.
病毒性肠胃炎是全科医疗和急诊科中最常见的腹泻疾病。本文旨在对儿童病毒性肠胃炎的评估与管理提供一篇叙述性的最新综述。
使用关键词“病毒性肠胃炎”通过临床查询在PubMed上进行检索。检索策略包括临床试验、荟萃分析、随机对照试验、观察性研究和综述。检索仅限于英文文献和儿科人群。
急性病毒性肠胃炎通常为自限性疾病。然而,如果治疗不当,可能会导致脱水和电解质失衡。应提供含有生理浓度葡萄糖和电解质的足够液体,以补充胃肠道损失并满足维持需求。对于轻度至中度脱水的儿童,口服补液疗法在补液方面与静脉输液疗法同样有效。通常无需检测血清电解质、肌酐和葡萄糖,仅对需要住院和静脉治疗的重度脱水儿童亚组才应考虑检测。谨慎使用昂丹司琼可提高口服补液疗法的成功率,并减少静脉治疗和住院的需求。
急性病毒性肠胃炎在发达国家会导致大量发病,在发展中国家会导致显著死亡。医生应教育护理人员保持适当的个人卫生和洗手,以预防病原体的粪口传播,以及轮状病毒疫苗在预防轮状病毒性肠胃炎方面的重要性。目前有几种诺如病毒疫苗正在进行临床试验,结果令人鼓舞。希望一种有效的诺如病毒疫苗的研发将进一步降低病毒性肠胃炎的发病率。