Mylotte Joseph M
Department of Medicine, Division of Infectious Diseases, School of Medicine and Biomedical Sciences, University at Buffalo, Erie County Medical Center, Buffalo, New York 14215, USA.
Clin Infect Dis. 2002 Nov 15;35(10):1205-11. doi: 10.1086/344281. Epub 2002 Oct 28.
Pneumonia is the most serious of the common infections that occur in nursing homes, with a high case-fatality rate and considerable mortality among survivors. Risk factors for nursing home-acquired pneumonia (NHAP) have been defined, and prediction models for death due to NHAP have been developed. The bacterial etiology of NHAP has been debated, but "typical" bacterial pathogens (Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis) are most important. Clinical presentation of NHAP is said to be "atypical," but this may be confounded by dementia in the nursing home resident. A recent guideline has made recommendations regarding the minimal diagnostic workup when a resident has a suspected case of pneumonia. Until recently, most guidelines for the treatment of pneumonia did not specifically address NHAP; there is some evidence that use of a quinolone alone may be an acceptable first choice of therapy for most cases. Pneumococcal and influenza vaccination have been the primary prevention measures. However, additional methods to prevent NHAP should be evaluated, including improving the oral hygiene of residents and instituting pharmacological interventions.
肺炎是养老院中常见感染里最严重的一种,病死率高,幸存者中也有相当数量的人死亡。养老院获得性肺炎(NHAP)的危险因素已被明确,并且已经开发出NHAP所致死亡的预测模型。NHAP的细菌病因一直存在争议,但“典型”细菌病原体(肺炎链球菌、流感嗜血杆菌和卡他莫拉菌)最为重要。据说NHAP的临床表现“不典型”,但这可能会因养老院居民患有痴呆症而混淆。最近的一项指南针对居民疑似肺炎病例时的最低限度诊断检查提出了建议。直到最近,大多数肺炎治疗指南都没有专门针对NHAP;有一些证据表明,单独使用喹诺酮类药物可能是大多数病例可接受的首选治疗方法。肺炎球菌疫苗接种和流感疫苗接种一直是主要的预防措施。然而,应该评估预防NHAP的其他方法,包括改善居民的口腔卫生和采取药物干预措施。