Kumar Arun, Styler Michael J, Topolsky David L, Crilley Pamela A, Przybysz Thomas M, Gladstone Douglas E
College of Medicine, Drexel University, 245 North 15th Street, Philadelphia, PA 19102, USA.
Am J Hematol. 2002 Nov;71(3):227-8. doi: 10.1002/ajh.10239.
The transplantation of malignant cells during allogeneic transplant is a rare occurrence. 27 months after donating progenitor cells, a diagnosis of multiple myeloma was made in a 6/6 HLA-phenotypically matched unrelated donor. The 42-year-old recipient transplanted for chronic phase chronic myeloid leukemia developed IgA myeloma 40 months after transplantation. Serum electrophoresis and bone marrow investigations established the diagnosis of IgA K multiple myeloma in both. This case illustrates the natural history and biology of multiple myeloma.
在同种异体移植过程中恶性细胞的移植是一种罕见的情况。在捐献祖细胞27个月后，一名6/6 HLA表型匹配的无关供者被诊断为多发性骨髓瘤。这位42岁因慢性期慢性髓性白血病接受移植的受者在移植40个月后发生了IgA骨髓瘤。血清电泳和骨髓检查确诊两人均为IgA K型多发性骨髓瘤。该病例说明了多发性骨髓瘤的自然病程和生物学特性。
