墨汁鬼伞中具有双硫仑样成分的鬼伞素的分离与结构研究。
Isolation and structural studies of coprine, the disulfiram-like constituent of Coprinus atramentarius.
作者信息
Hatfield G M, Schaumberg J P
出版信息
Lloydia. 1975 Nov-Dec;38(6):489-96.
PMID:1241098
Abstract
Coprine, the constituent of the mushroom Coprinus atramentarius Fr. responsible for its disulfiram-like activity, was isolated. Chemical and spectral data indicate that the compound is N5-(1-hydroxycyclopropyl)glutamine. Although coprine was shown to produce hyperaldehydemia in mice following ethanol ingestion, the compound was not found to be an inhibitor of mouse liver aldehyde dehydrogenase in vitro.
摘要
鬼伞素是墨汁鬼伞（Coprinus atramentarius Fr.）中的一种成分，其具有双硫仑样活性，现已被分离出来。化学和光谱数据表明该化合物为N5-(1-羟基环丙基)谷氨酰胺。尽管已证明鬼伞素在小鼠摄入乙醇后会导致高醛血症，但在体外实验中未发现该化合物是小鼠肝脏醛脱氢酶的抑制剂。
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