子宫腺肌病患者血管内皮生长因子表达的研究

[Study on the expression of vascular endothelial growth factor in patients with adenomyosis of the uterus].

作者信息

Han Yanhua, Zhou Yingfang, Zheng Shurong

机构信息

Department of Obstetrics and Gynecology, Zhongshan City People's Hospital, Guangdong Province, Zhongshan 528403, China.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 2002 Sep;37(9):539-41.

PMID:12411015

Abstract

OBJECTIVE

To investigate the role of angiogenesis and expression of vascular endothelial growth factor (VEGF) in the pathophysiology of adenomyosis of the uterus.

METHODS

The study included 32 patients with histologically proven adenomyosis and 30 patients with asymptomatic leiomyoma of the uterus. Immunohistochemical staining was used to detect VEGF expression in different parts of the uterus. A computerized morphometric study on the VEGF expression was performed.

RESULTS

The VEGF H-Score of glandular cells in the endometrium of adenomyosis uterus [proliferative phase (9.6 +/- 1.4), secretory phase (11.7 +/- 1.6)] was much higher than that of leiomyoma uterus [proliferative phase (8.3 +/- 1.7), secretory phase (10.2 +/- 1.5)] (P < 0.05), and increased in the secretory phase (P < 0.05). Compared with eutopic endometrium, the VEGF H-Score in ectopic endometrium [proliferative phase (11.9 +/- 1.8), secretory phase (13.0 +/- 1.7)] increased significantly (P < 0.05), but showed no cyclic change (P > 0.05). The VEGF H-Score of myometrium around the ectopic lesions [proliferative phase (9.5 +/- 1.3), secretory phase (8.7 +/- 1.3)] was higher than that of normal myometrium [proliferative phase (4.8 +/- 1.9), secretory phase (4.5 +/- 1.4)] (P < 0.01).

CONCLUSION

The angiogenesis activity of the endometrium and myometrium of adenomyosis uterus was markedly increased.

摘要

目的

探讨血管生成及血管内皮生长因子（VEGF）表达在子宫腺肌病病理生理学中的作用。

方法

本研究纳入32例经组织学证实的子宫腺肌病患者和30例无症状子宫平滑肌瘤患者。采用免疫组织化学染色检测子宫不同部位的VEGF表达。对VEGF表达进行计算机形态计量学研究。

结果

子宫腺肌病患者子宫内膜腺上皮细胞的VEGF H评分[增殖期（9.6±1.4），分泌期（11.7±1.6）]显著高于子宫平滑肌瘤患者[增殖期（8.3±1.7），分泌期（10.2±1.5）]（P<0.05），且在分泌期升高（P<0.05）。与在位内膜相比，异位内膜的VEGF H评分[增殖期（11.9±1.8），分泌期（13.0±1.7）]显著升高（P<0.05），但无周期性变化（P>0.05）。异位病灶周围肌层的VEGF H评分[增殖期（9.5±1.3），分泌期（8.7±1.3）]高于正常肌层[增殖期（4.8±1.9），分泌期（4.5±1.4）]（P<0.01）。