Reese David E, Mikawa Takashi, Bader David M
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY, USA.
Circ Res. 2002 Nov 1;91(9):761-8. doi: 10.1161/01.res.0000038961.53759.3c.
Formation of the coronary vessels is a fundamental event in heart development. Congenital abnormalities in the coronary system can have major deleterious effects on heart function. It is also possible that subtle variation in the patterning of coronary vessels has significant but uncharacterized effects on myocardial structure and function. In addition, generation of the coronary vascular system represents a complex system for analysis of regulation of cell fate determination, cell and epithelial migration, epithelial/mesenchymal transition, and patterning of a complex three-dimensional structure. In this review, we present the descriptive embryology of this process as well as the recent data that shed light on the unique developmental mechanisms underlying generation of coronary vessels. This review also attempts to identify areas where additional research is needed and highlights the questions that must be answered for a meaningful understanding of coronary vessel development.
冠状动脉的形成是心脏发育中的一个基本事件。冠状动脉系统的先天性异常可对心脏功能产生重大有害影响。冠状动脉血管模式的细微变化也可能对心肌结构和功能产生显著但尚未明确的影响。此外，冠状动脉系统的生成代表了一个复杂的系统，可用于分析细胞命运决定、细胞和上皮迁移、上皮/间充质转化以及复杂三维结构模式的调控。在这篇综述中，我们介绍了这一过程的描述性胚胎学以及揭示冠状动脉生成独特发育机制的最新数据。这篇综述还试图确定需要进一步研究的领域，并强调为了有意义地理解冠状动脉发育必须回答的问题。
