Wada Aya M, Willet Spencer G, Bader David
Stahlman Cardiovascular Laboratories, Program for Developmental Biology, Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tenn, USA.
Arterioscler Thromb Vasc Biol. 2003 Dec;23(12):2138-45. doi: 10.1161/01.ATV.0000098645.38676.CC. Epub 2003 Oct 2.
Development of the coronary vascular system is an interesting model in developmental biology with major implications for the clinical setting. Although coronary vessel development is a form of vasculogenesis followed by angiogenesis, this system uses several unique developmental processes not observed in the formation of other blood vessels. This review summarizes the literature that describes the development of the coronary system, highlighting the unique aspects of coronary vessel development. It should be noted that many of the basic mechanisms that govern vasculogenesis in other systems have not been analyzed in coronary vessel development. In addition, we present recent advances in the field that uncover the basic mechanisms regulating the generation of these blood vessels and identify areas in need of additional studies.
冠状动脉系统的发育是发育生物学中一个有趣的模型，对临床具有重要意义。尽管冠状动脉发育是血管生成继之以血管形成的一种形式，但该系统使用了一些在其他血管形成过程中未观察到的独特发育过程。本综述总结了描述冠状动脉系统发育的文献，突出了冠状动脉发育的独特方面。应该注意的是，许多在其他系统中调控血管生成的基本机制尚未在冠状动脉发育中进行分析。此外，我们介绍了该领域的最新进展，这些进展揭示了调节这些血管生成的基本机制，并确定了需要进一步研究的领域。
