Mauad Filho F, Meirelles R S
Rev Bras Pesqui Med Biol. 1975 Sep-Dec;8(5-6):401-13.
In the present work ketamine was used as anesthetic during the labor in order to evaluate the effect of this anesthetic on the binominal fetus-mother. Two groups of parturients and their fetuses, were studied: 1) The experimental group, with 22 parturients and their fetuses submitted to ketamine anesthesia during the labord, and 2) The control group, with 20 parturients and their fetuses without any analgesic treatment during the labor. In 20 cases of the experimental group the anesthetic was injected during the delivery labor and the other two just before it. It were evaluated in the mother's blood the biochemical parameters of the acid-base balance and others collateral effects of the anesthesia; on the fetus's side the same parameters also and the cardiac frequency. The newborn were evaluated by Apgar Score during the first and fifth minutes of life. The incidence of the spontaneous delivery in the experimental group, was 78%; in 22% of these patients the forceps of relief was used. In 22 cases in which Ketamine was applied it were observed, the following events: elevation of the blood pressure (50%), perineum rigidness (18%), dreams and or hallucinations (18%), increase of the cardiac frequency (9%), apneia (4%) and nausea (4%). It was also observed an increase of uterine tonus an abolishment of abdominal press during the delivery labor, studied through the uterine electromyography register. It was noted after the Ketamine application a fall in the pH of the maternal peripherical venous blood, fetal skull blood and the pH of the blood of the umbilical vein. 22% of the newborns, from the experimental group, presented a depression in the first minute of life (Apgar less than or equals to 6). The pCO2 values in the blood of the umbilical artery were higher in the experimental group than in the control one.
在本研究中,氯胺酮被用作分娩期间的麻醉剂,以评估这种麻醉剂对母婴二元体的影响。研究了两组产妇及其胎儿:1)实验组,22名产妇及其胎儿在分娩期间接受氯胺酮麻醉;2)对照组,20名产妇及其胎儿在分娩期间未接受任何镇痛治疗。实验组中20例在分娩时注射麻醉剂,另外两例在分娩前注射。评估了母亲血液中的酸碱平衡生化参数以及麻醉的其他附带影响;在胎儿方面,也评估了相同的参数以及心率。在新生儿出生后的第一分钟和第五分钟通过阿普加评分进行评估。实验组自然分娩的发生率为78%;这些患者中有22%使用了助产钳。在应用氯胺酮的22例病例中,观察到以下情况:血压升高(50%)、会阴僵硬(18%)、梦境和/或幻觉(18%)、心率增加(9%)、呼吸暂停(4%)和恶心(4%)。通过子宫肌电图记录还观察到分娩时子宫张力增加和腹压消失。应用氯胺酮后,注意到母体外周静脉血、胎儿颅骨血和脐静脉血的pH值下降。实验组中有22%的新生儿在出生后第一分钟出现抑制(阿普加评分小于或等于6)。实验组脐动脉血中的pCO2值高于对照组。