用（99m）锝-甲氧基异丁基异腈单光子发射计算机断层扫描评估小儿中枢神经系统恶性肿瘤。

Evaluation of pediatric CNS malignancies with (99m)Tc-methoxyisobutylisonitrile SPECT.

作者信息

Kirton Adam, Kloiber Reinhard, Rigel Jane, Wolff Johannes

机构信息

Department of Pediatrics, Alberta Children's Hospital, University of Calgary, Canada.

出版信息

J Nucl Med. 2002 Nov;43(11):1438-43.

PMID:12411545

Abstract

UNLABELLED

SPECT has the potential to add valuable information to the diagnosis and management of central nervous system (CNS) malignancy. Radioactive tracers including (99m)Tc-methoxyisobutylisonitrile (MIBI), or sestamibi, have been shown to be sensitive markers for brain tumors; however, their role in imaging children is poorly defined.

METHODS

We undertook a pilot study of 29 pairs of (99m)Tc-MIBI and MRI images from 20 children to explore the clinical usefulness of this tracer in CNS malignancy.

RESULTS

Tumor types that took up (99m)Tc-MIBI included brain stem glioma, fibrillary astrocytoma, other low-grade astrocytomas, and glioblastoma multiforme. Most tumors positive for (99m)Tc-MIBI uptake were astrocytomas, including those in the brain stem, cerebellum, and cortex. This method of nuclear imaging not only was able to identify the presence of a tumor but also could identify changes in the same tumor over time. Some correlation between histologic grade and (99m)Tc-MIBI uptake was observed. Several tumors, including craniopharyngioma, medulloblastoma, and optic glioma, were evident on MRI but not on (99m)Tc-MIBI SPECT.

CONCLUSION

The results suggest that this modality is a potentially useful tool in the diagnosis and management of CNS malignancies, particularly higher-grade astrocytomas, in children.

摘要

未标注

单光子发射计算机断层扫描（SPECT）有潜力为中枢神经系统（CNS）恶性肿瘤的诊断和管理增添有价值的信息。包括（99m）锝-甲氧基异丁基异腈（MIBI）或司他米比在内的放射性示踪剂已被证明是脑肿瘤的敏感标志物；然而，它们在儿童成像中的作用尚不清楚。

方法

我们对20名儿童的29对（99m）Tc-MIBI和MRI图像进行了一项初步研究，以探讨这种示踪剂在CNS恶性肿瘤中的临床实用性。

结果

摄取（99m）Tc-MIBI的肿瘤类型包括脑干胶质瘤、纤维型星形细胞瘤、其他低级别星形细胞瘤和多形性胶质母细胞瘤。大多数对（99m）Tc-MIBI摄取呈阳性的肿瘤是星形细胞瘤，包括脑干、小脑和皮质中的肿瘤。这种核成像方法不仅能够识别肿瘤的存在，还能够识别同一肿瘤随时间的变化。观察到组织学分级与（99m）Tc-MIBI摄取之间存在一些相关性。包括颅咽管瘤、髓母细胞瘤和视神经胶质瘤在内的几种肿瘤在MRI上明显，但在（99m）Tc-MIBI SPECT上不明显。