Sakai Michio, Shirahata Akira, Akatsuka Jun-ichi, Fujisawa Kohji, Ohkawa Hiroji, Konishi Shozaburo, Bessho Fumio, Miyazaki Sumio
Department of Education of the Early Childhood, Seitoku University.
Rinsho Ketsueki. 2002 Sep;43(9):821-7.
Three antiphospholipid antibodies (aPLs), namely, antiphosphatidylinositol antibody (antiinositol antibody), antiphosphatidylserine antibody (antiserine antibody), and anticardiolipin. beta 2-glycoprotein I complex antibody (antiCL. beta 2-GPI antibody), were determined in 49 children with idiopathic thrombocytopenic purpura (ITP) consisting of 14 newly-diagnosed cases and 35 chronic cases. Determination of aPL was performed twice in the newly-diagnosed patients, once each during the acute and convalescent phases, and once in the chronic patients. The positive rates in the acute and convalescent phases of the newly-diagnosed group and in the chronic group were, respectively, 14.3%, 28.6%, and 18.8% for the antiinositol antibody, 14.3%, 14.3%, and 15.6% for the antiserine antibody, and 21.4%, 28.6%, and 25.0% for either of these 2 antibodies. Thus, antiinositol and antiserine aPLs were present at high incidences; however, all patients were negative for the antiCL. beta 2-GPI antibody. No correlation was noted between either the antiinositol or the antiserine antibody and peripheral platelet count, anti-GP IIb/IIIa antibody or PAIgG. Thus, although some aPLs are present in both acute and chronic pediatric ITP, the aPLs seems to be of an infectious disease type. No results that suggest possible involvement of aPLs in ITP pathology were obtained.
在49例特发性血小板减少性紫癜（ITP）患儿中检测了三种抗磷脂抗体（aPLs），即抗磷脂酰肌醇抗体（抗肌醇抗体）、抗磷脂酰丝氨酸抗体（抗丝氨酸抗体）和抗心磷脂-β2糖蛋白I复合物抗体（抗CL-β2-GPI抗体），其中包括14例新诊断病例和35例慢性病例。对新诊断患者进行了两次aPL检测，急性和恢复期各一次，对慢性患者检测了一次。新诊断组急性和恢复期以及慢性组中，抗肌醇抗体的阳性率分别为14.3%、28.6%和18.8%，抗丝氨酸抗体的阳性率分别为14.3%、14.3%和15.6%，这两种抗体中任一种的阳性率分别为21.4%、28.6%和25.0%。因此，抗肌醇和抗丝氨酸aPLs的发生率较高；然而，所有患者的抗CL-β2-GPI抗体均为阴性。抗肌醇或抗丝氨酸抗体与外周血小板计数、抗GP IIb/IIIa抗体或PAIgG之间均未发现相关性。因此，尽管在儿童急性和慢性ITP中均存在一些aPLs，但这些aPLs似乎属于感染性疾病类型。未获得提示aPLs可能参与ITP病理过程的结果。
