Krusz John Claude
Anodyne Pain Care, 5446 Glen Lakes Drive, Dallas, TX 75231, USA.
Curr Pain Headache Rep. 2002 Dec;6(6):480-5. doi: 10.1007/s11916-002-0067-9.
Approaches to acute and prophylactic migraine and headache treatment are evolving as our understanding of some of the underlying pathophysiology improves. This article focuses on the emerging use of medications originally introduced for the treatment of seizures (anticonvulsants) as primary therapy for eradicating or reducing migraine and chronic daily headaches. A more accurate term for their pharmacologic mechanisms, if they are used to treat headaches and pain disorders, is neuromodulating or neuronal stabilizing agents. This term refers to their many cellular actions to reduce pain transmission supraspinally, in the spinal cord, and in the brainstem.
随着我们对某些潜在病理生理学的理解不断深入，急性偏头痛和预防性偏头痛及头痛的治疗方法也在不断发展。本文重点关注最初用于治疗癫痫的药物（抗惊厥药）作为根除或减轻偏头痛和慢性每日头痛的主要疗法的新用途。如果它们用于治疗头痛和疼痛性疾病，更准确地描述其药理机制的术语是神经调节或神经元稳定药物。该术语指的是它们在脊髓、脑干及脊髓以上水平减少疼痛传递的多种细胞作用。
