Messer Walter
Max-Planck-Institut für molekulare Genetik, Ihnestrasse 73, D-14195 Berlin-Dahlem, Germany.
FEMS Microbiol Rev. 2002 Nov;26(4):355-74. doi: 10.1111/j.1574-6976.2002.tb00620.x.
The initiation of replication is the central event in the bacterial cell cycle. Cells control the rate of DNA synthesis by modulating the frequency with which new chains are initiated, like all macromolecular synthesis. The end of the replication cycle provides a checkpoint that must be executed for cell division to occur. This review summarizes recent insight into the biochemistry, genetics and control of the initiation of replication in bacteria, and the central role of the initiator protein DnaA.
复制起始是细菌细胞周期中的核心事件。与所有大分子合成一样，细胞通过调节新链起始的频率来控制DNA合成的速率。复制周期的结束提供了一个检查点，细胞分裂必须通过该检查点才能发生。本综述总结了对细菌复制起始的生物化学、遗传学和调控的最新见解，以及起始蛋白DnaA的核心作用。
