Risbud Makarand V, Bhonde Ramesh R
Tissue Engineering and Banking Laboratory, National Centre for Cell Sciences, Ganeshkhind, Pune 411 007, India.
Diabetes Res Clin Pract. 2002 Dec;58(3):155-65. doi: 10.1016/s0168-8227(02)00103-1.
The number of functionally intact beta cells in the islet organ is of decisive importance for the development, course and outcome of diabetes mellitus. Generally speaking, the total beta-cell mass reflects the balance between the renewal and loss of these cells. Assuming that virtually all forms of diabetes mellitus are characterized by an insufficient extent of beta cell replication needed to compensate for the loss or dysfunction of beta cells occurring in diabetes, elucidation of the regenerating potential in experimentally induced diabetic animal would be of interest as alternative therapy for diabetes. Here we have attempted to take a stock of different models developed in the last few years, which permit investigation of regenerative process from various angles. The review focuses on factors responsible for induction of islet neogenesis in the diabetic pancreas, ultimately leading to pancreatic regeneration and possible reversal of diabetes. On the whole the study of these models will enhance our understanding of regenerative potential of diabetic pancreas and factors necessary to trigger stem cells' population within the pancreas so as to suggest an alternative therapeutic approach for the control and/or cure of diabetes.
胰岛器官中功能完好的β细胞数量对于糖尿病的发生、发展过程及预后起着决定性作用。一般来说，β细胞的总体数量反映了这些细胞更新与损耗之间的平衡。假设几乎所有类型的糖尿病都具有这样的特征，即补偿糖尿病中发生的β细胞丢失或功能障碍所需的β细胞复制程度不足，那么阐明实验性诱导糖尿病动物的再生潜力作为糖尿病的替代疗法将是有意义的。在此，我们试图梳理过去几年开发的不同模型，这些模型允许从各个角度研究再生过程。这篇综述聚焦于糖尿病胰腺中诱导胰岛新生的相关因素，最终导致胰腺再生以及糖尿病可能的逆转。总体而言，对这些模型的研究将增进我们对糖尿病胰腺再生潜力以及触发胰腺内干细胞群所需因素的理解，从而为控制和/或治愈糖尿病提出一种替代治疗方法。
