Tao Jing, Morikawa Toshio, Toguchida Iwao, Ando Shin, Matsuda Hisashi, Yoshikawa Masayuki
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, Japan.
Bioorg Med Chem. 2002 Dec;10(12):4005-12. doi: 10.1016/s0968-0896(02)00314-0.
Three new biphenyl type diarylheptanoid glycosides, myricanol 11-O-beta-D-glucopyranoside, myricanone 5-O-beta-D-glucopyranoside, and neomyricanone 5-O-beta-D-glucopyranoside, and a new taraxerane type triterpene, myricetrione, were isolated from the bark of Chinese Myrica rubra. Their structures were elucidated on the basis of chemical and physicochemical evidence. Biphenyl type diarylheptanoids, triterpene, and their polyphenols showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-activated macrophages. Furthermore, diarylheptanoids, myricanol and myricanone, were found to inhibit induction of inducible nitric oxide synthase.
从中国杨梅的树皮中分离出三种新的联苯型二芳基庚烷糖苷，即杨梅醇11 - O - β - D - 吡喃葡萄糖苷、杨梅酮5 - O - β - D - 吡喃葡萄糖苷和新杨梅酮5 - O - β - D - 吡喃葡萄糖苷，以及一种新的蒲公英烷型三萜，杨梅三萜酮。基于化学和物理化学证据阐明了它们的结构。联苯型二芳基庚烷类化合物、三萜及其多酚对脂多糖激活的巨噬细胞中一氧化氮的产生具有显著的抑制作用。此外，还发现二芳基庚烷类化合物杨梅醇和杨梅酮可抑制诱导型一氧化氮合酶的诱导。
