R M Ibrahim Sabrin, A Mohamed Gamal, I M Khedr Amgad, M Aljaeid Bader
Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawarah 30078, Saudi Arabia.
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
Iran J Pharm Res. 2017 Winter;16(Suppl):83-91.
A new cyclic diarylheptanoid namely alnuheptanoid B (3), along with four known cyclic diarylheptanoids: myricanone (1), (+)--myricanol (2), myricanone 5-- -D-glucopyranoside (4), and (+)--myricanol 5-- -D-glucopyranoside (5) were isolated from the EtOAc fraction of Steud (family: Betulaceae) stem bark. Their structures were established by different spectroscopic analyses, as well as optical rotation measurement. Compounds 1, 2, 4, and 5 are isolated for the first time from . . The antioxidant and anti-inflammatory activities of compounds (1-5) were assessed using DPPH assay and carrageenin induced rat paw edema model, respectively. They displayed significant antioxidant activity in relation to propyl gallate (standard antioxidant) at concentration 50 M. Compound 2 demonstrated anti-inflammatory effect at a dose 10 mg/kg compared with indomethacin (positive control).
一种新的环状二芳基庚烷类化合物，即桤木庚烷类化合物B（3），与四种已知的环状二芳基庚烷类化合物：杨梅酮（1）、（+）-β-杨梅醇（2）、杨梅酮5-O-β-D-吡喃葡萄糖苷（4）和（+）-β-杨梅醇5-O-β-D-吡喃葡萄糖苷（5）一起，从桦木科桤木属植物的茎皮乙酸乙酯萃取物中分离得到。它们的结构通过不同的光谱分析以及旋光度测量得以确定。化合物1、2、4和5首次从……中分离得到。分别使用DPPH法和角叉菜胶诱导的大鼠足趾肿胀模型评估了化合物（1-5）的抗氧化和抗炎活性。在50 μM浓度下，它们相对于没食子酸丙酯（标准抗氧化剂）表现出显著的抗氧化活性。与吲哚美辛（阳性对照）相比，化合物2在10 mg/kg剂量下表现出抗炎作用。
