Youn Tak, Park Hae-Jeong, Kim Jae-Jin, Kim Myung Sun, Kwon Jun Soo
Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
Schizophr Res. 2003 Feb 1;59(2-3):253-60. doi: 10.1016/s0920-9964(02)00154-8.
The abnormality of mismatch negativity (MMN) in schizophrenia is thought to be associated with perceptional disturbance and cognitive dysfunction. The purpose of the present study was to investigate the change of the normal functional hemispheric lateralization in schizophrenia by employing the equivalent current dipole (ECD) model of auditory MMN with individual MRI and high-density electroencephalography (EEG). The MMNs resulting from auditory stimuli with passive oddball paradigm in a group of schizophrenics (n = 15), and also a group of age-, sex-, and handedness-matched normal controls, were recorded by 128 channel EEG. The location and power of ECD sources at the peak point were calculated. Individual 3-D brain magnetic resonance images (MRI) were used for realistic head modeling and for source localization. For both groups, the MMN source was determined to be located in the superior temporal gyrus (STG). However, the normal functional hemispheric asymmetry of ECD power was significantly altered in the schizophrenics (chi(2) test = 16.13, p < 0.001). Left MMN ECD power and the asymmetry coefficient (AC) were negatively correlated with the positive scores from Positive and Negative Syndrome Scale (PANSS) (r = -0.673, p = 0.008), especially with the hallucinatory behavior subscale (r = -0.677, p = 0.008). These findings support the deficits in preattentive automatic processing of auditory stimuli, especially in the left hemisphere, and indicate the correlation between positive symptoms, especially auditory hallucination, and left temporal lobe dysfunction in schizophrenia.
精神分裂症中失匹配负波（MMN）异常被认为与感知障碍和认知功能障碍有关。本研究的目的是通过采用基于个体磁共振成像（MRI）和高密度脑电图（EEG）的听觉MMN等效电流偶极子（ECD）模型，来研究精神分裂症患者正常功能的半球偏侧化变化。通过128导EEG记录了一组精神分裂症患者（n = 15）以及一组年龄、性别和利手匹配的正常对照在被动奇数球范式下听觉刺激产生的MMN。计算了ECD源在峰值点的位置和功率。使用个体三维脑磁共振图像（MRI）进行逼真的头部建模和源定位。两组的MMN源均被确定位于颞上回（STG）。然而，精神分裂症患者ECD功率的正常功能半球不对称性发生了显著改变（卡方检验 = 16.13，p < 0.001）。左侧MMN的ECD功率和不对称系数（AC）与阳性和阴性症状量表（PANSS）的阳性得分呈负相关（r = -0.673，p = 0.008），尤其是与幻觉行为子量表呈负相关（r = -0.677，p = 0.008）。这些发现支持了精神分裂症患者在听觉刺激的前注意自动加工方面存在缺陷，尤其是在左半球，并表明阳性症状，特别是幻听，与精神分裂症患者左颞叶功能障碍之间存在相关性。
