Tanabe Jody, Tregellas Jason, Miller David, Ross Randal G, Freedman Robert
Department of Radiology, University of Colorado Health Sciences Center, Denver, 80262, USA.
Neuroimage. 2002 Nov;17(3):1315-24. doi: 10.1006/nimg.2002.1263.
A potential application of studying eye movements with functional MRI (fMRI) is to examine patient populations with known eye movement dysfunction, but the reliability with which normal subjects demonstrate activity in specific brain regions has not been established. To date, fMRI studies of smooth-pursuit eye movements have used relatively small numbers of subjects and have been restricted to fixed-effects analyses. We extend these studies to whole brain imaging at 1.5 T, properly accounting for intersubject variation using random effects analysis. Smooth-pursuit eye movements elicited activation consistently in dorsal cortical eye fields and cerebellum. Subcortical activation was greatly attenuated, but not eliminated, with the random-effects second-level analysis. In addition, session-dependent changes in activation were greater in some regions than others and may indicate areas of brain, such as the supplementary eye fields, that are sensitive to attentional modulation of eye movements.
使用功能磁共振成像（fMRI）研究眼球运动的一个潜在应用是检查已知存在眼球运动功能障碍的患者群体，但正常受试者在特定脑区表现出活动的可靠性尚未得到证实。迄今为止，对平稳跟踪眼球运动的fMRI研究使用的受试者数量相对较少，并且仅限于固定效应分析。我们将这些研究扩展到1.5T的全脑成像，使用随机效应分析适当考虑受试者间的差异。平稳跟踪眼球运动在背侧皮质眼区和小脑持续引发激活。经随机效应二级分析，皮质下激活大大减弱，但并未消除。此外，某些区域的激活随实验时段的变化比其他区域更大，这可能表明大脑中诸如辅助眼区等对眼球运动的注意力调制敏感的区域。
