Gillberg Peter, Mallmin Hans, Petrén-Mallmin Marianne, Ljunghall Sverker, Nilsson Anna G
Department of Medical Sciences, University Hospital, S-75185 Uppsala, Sweden.
J Clin Endocrinol Metab. 2002 Nov;87(11):4900-6. doi: 10.1210/jc.2002-020231.
We have investigated the effects of GH treatment on bone turnover, bone size, bone mineral density (BMD), and bone mineral content (BMC) in 29 men, 27-62 yr old, with idiopathic osteoporosis. The patients were randomly assigned to treatment with GH, either as continuous treatment with daily injections of 0.4 mg GH/d (group A, n = 14) or as intermittent treatment with 0.8 mg GH/d for 14 d every 3 months (group B, n = 15). All patients were treated with GH for 24 months, with a follow-up period of 12 months, and also received 500 mg calcium and 400 U vitamin D3 daily during all 36 months. Fasting morning urine and serum samples were obtained for assay of IGF-I, bone markers, and routine laboratory tests at baseline, after 1, 12, 24, and 36 months. Body composition, BMD, and BMC were determined by dual-energy x-ray absorptiometry at baseline and every 6 months. After 2 yr, there was an increase in BMD in lumbar spine (by 4.1%) in group A, and in total body (by 2.6%) in group A and (by 2.7%) in group B. BMC of the total body and lean body mass increased, whereas fat mass decreased in both treatment groups. After 36 months, the BMD and BMC in lumbar spine and total body had increased further in both groups. We conclude that 2 yr of intermittent or continuous treatment with GH in men with idiopathic osteoporosis results in an increase in BMD and BMC that is sustained for at least 1 yr post treatment.
我们研究了生长激素（GH）治疗对29名年龄在27至62岁之间的特发性骨质疏松症男性患者的骨转换、骨大小、骨矿物质密度（BMD）和骨矿物质含量（BMC）的影响。患者被随机分配接受GH治疗，其中一组为每日注射0.4mg GH的持续治疗（A组，n = 14），另一组为每3个月注射0.8mg GH共14天的间歇治疗（B组，n = 15）。所有患者接受GH治疗24个月，随访期为12个月，并且在整个36个月期间每天还接受500mg钙和400U维生素D3。在基线、1个月、12个月、24个月和36个月时采集空腹晨尿和血清样本，用于检测胰岛素样生长因子-I（IGF-I）、骨标志物和常规实验室检查。在基线和每6个月时通过双能X线吸收法测定身体成分、BMD和BMC。2年后，A组腰椎BMD增加了4.1%，A组全身BMD增加了2.6%，B组全身BMD增加了2.7%。两个治疗组的全身BMC和去脂体重均增加，而脂肪量减少。36个月后，两组腰椎和全身的BMD和BMC进一步增加。我们得出结论，对特发性骨质疏松症男性患者进行2年的GH间歇或持续治疗可导致BMD和BMC增加，且治疗后至少持续1年。
