Lindsey Richard C, Mohan Subburaman
Musculoskeletal Disease Center, Loma Linda VA Healthcare System, Loma Linda, CA 92357, USA; Department of Medicine, Loma Linda University, Loma Linda, CA 92354, USA; Department of Biochemistry, Loma Linda University, Loma Linda, CA 92354, USA.
Musculoskeletal Disease Center, Loma Linda VA Healthcare System, Loma Linda, CA 92357, USA; Department of Medicine, Loma Linda University, Loma Linda, CA 92354, USA; Department of Biochemistry, Loma Linda University, Loma Linda, CA 92354, USA.
Mol Cell Endocrinol. 2016 Sep 5;432:44-55. doi: 10.1016/j.mce.2015.09.017. Epub 2015 Sep 25.
The growth hormone/insulin-like growth factor (GH/IGF) axis is critically important for the regulation of bone formation, and deficiencies in this system have been shown to contribute to the development of osteoporosis and other diseases of low bone mass. The GH/IGF axis is regulated by a complex set of hormonal and local factors which can act to regulate this system at the level of the ligands, receptors, IGF binding proteins (IGFBPs), or IGFBP proteases. A combination of in vitro studies, transgenic animal models, and clinical human investigations has provided ample evidence of the importance of the endocrine and local actions of both GH and IGF-I, the two major components of the GH/IGF axis, in skeletal growth and maintenance. GH- and IGF-based therapies provide a useful avenue of approach for the prevention and treatment of diseases such as osteoporosis.
生长激素/胰岛素样生长因子（GH/IGF）轴对于骨形成的调节至关重要，并且已表明该系统的缺陷会导致骨质疏松症和其他低骨量疾病的发生。GH/IGF轴由一组复杂的激素和局部因子调节，这些因子可在配体、受体、IGF结合蛋白（IGFBPs）或IGFBP蛋白酶水平上调节该系统。体外研究、转基因动物模型和临床人体研究相结合，充分证明了GH/IGF轴的两个主要组成部分GH和IGF-I的内分泌和局部作用在骨骼生长和维持中的重要性。基于GH和IGF的疗法为预防和治疗骨质疏松症等疾病提供了一条有用的途径。
