Mazhar D, Waxman J
Department of Cancer Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK.
Postgrad Med J. 2002 Oct;78(924):590-5. doi: 10.1136/pmj.78.924.590.
It is a paradigm in cancer treatment that early detection and treatment improves survival. However, although screening measures lead to a higher rate of detection, for small bulk localised prostate cancer it remains unclear whether early detection and early treatment will lead to an overall decrease in mortality. The management options include surveillance, radiotherapy, and radical prostatectomy but there is no evidence base to evaluate the benefits of each approach. Advanced prostate cancer is managed by hormonal therapy. There have been major changes in treatment over the last two decades with the use of more humane treatment and developments in both chemotherapy and radiation. In this article we review the natural history and management of prostate cancer.
癌症治疗的一个范例是早期发现和治疗可提高生存率。然而，尽管筛查措施能提高检测率，但对于小体积局限性前列腺癌，早期发现和早期治疗是否会导致总体死亡率下降仍不明确。治疗选择包括监测、放疗和根治性前列腺切除术，但尚无证据基础来评估每种方法的益处。晚期前列腺癌采用激素治疗。在过去二十年中，随着采用更人道的治疗方法以及化疗和放疗的发展，治疗发生了重大变化。在本文中，我们回顾了前列腺癌的自然病程和治疗方法。
