Walczak Janet R, Carducci Michael A
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans St, Baltimore, MD 21231, USA.
Mayo Clin Proc. 2007 Feb;82(2):243-9. doi: 10.4065/82.2.243.
Prostate cancer is the leading cause of cancer in men in the United States, with 234,460 men expected to be diagnosed as having the disease in 2006 (33% of cancers in men), and the third leading cause of cancer deaths in men, with 27,350 men expected to die of the disease (9% of cancer deaths). Through early detection and improved local therapies, including surgery or radiation therapy, a large number of men will be cured, but unfortunately, a significant number of men will still experience relapse of disease and require continued surveillance and ongoing therapy. This article discusses approaches to treatment of men who have recurrent disease, including active surveillance, androgen ablation therapy, secondary hormone therapy, chemotherapy, bisphosphonates, radiation therapy, and future directions.
前列腺癌是美国男性癌症的主要病因，预计2006年有234,460名男性被诊断患有该病（占男性癌症的33%），也是男性癌症死亡的第三大主要病因，预计有27,350名男性死于该病（占癌症死亡的9%）。通过早期检测和改进的局部治疗方法，包括手术或放射治疗，大量男性将被治愈，但不幸的是，仍有相当数量的男性会经历疾病复发，需要持续监测和进行治疗。本文讨论了复发性疾病男性的治疗方法，包括主动监测、雄激素剥夺疗法、二线激素疗法、化疗、双膦酸盐、放射治疗以及未来的发展方向。
