Sengör Atilla, Ozkarakaş Haluk, Erçin Cengiz, Memişoğlu Ilknur
Department of Otolaryngology, Medicine Faculty of Kocaeli University, 41100 Derince, Izmit, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2002 May-Jun;9(3):216-9.
CD56 positive natural killer T cell lymphoma is characterized by destructive lesions in the nasal cavity and nasopharynx. Severe tissue necrosis makes histopathologic diagnosis difficult, generally necessitating multiple biopsies. A thirty-three-year-old male patient presented with complaints of nasal obstruction, hemorrhagic discharge of fetid odor, and rhinolalia. Immunohistochemical studies on biopsy specimens obtained from the lesion in the nasal septum and posterior nasal cavity revealed CD56 positive natural killer T cell lymphoma. The patient was treated with eight courses of combination chemotherapy, since then he has been in remission for more than 1.5 years.
CD56阳性自然杀伤T细胞淋巴瘤的特征是鼻腔和鼻咽部出现破坏性病变。严重的组织坏死使得组织病理学诊断困难，通常需要多次活检。一名33岁男性患者出现鼻塞、恶臭血性分泌物及鼻音症状。对取自鼻中隔和后鼻腔病变处的活检标本进行免疫组化研究，结果显示为CD56阳性自然杀伤T细胞淋巴瘤。该患者接受了8个疗程的联合化疗，此后已缓解超过1.5年。
