Zhou Chong, Bu Xiangzhao, Li Xiangyang, Liu Ling, Xie Xiaomei, Zhuo Shichao, Yin Haitao
Department of Radiation Oncology, The Central Hospital of Xuzhou, Liberation, No. 199 South Rd, Xuzhou, 221009, Jiang Su, China.
Department of Pathology, The Central Hospital of Xuzhou, Xuzhou, 221009, China.
Cell Biochem Biophys. 2015 Sep;73(1):17-20. doi: 10.1007/s12013-015-0563-2.
We report here a case of nasal natural killer/T-cell lymphoma with metastasization into the pancreas. A 43-year-old Chinese female patient presented with right nasal obstruction and purulent rhinorrhea that lasted for the past half year and worsened gradually despite antibiotic medical treatment. Physical examination revealed a mass in the right nasal cavity and an enlarged lymph node in the right submandibular region. A PET/CT scan and immunostaining of the resectate led to a diagnosis of nasal natural killer/T-cell lymphoma, clinical stage IIE, and the International Prognostic Index score of 1. The patient received radiotherapy followed by four cycles of the CHOP chemotherapy. A complete remission was achieved, and the patient was disease-free for 9 months. On a subsequent follow-up, abdominal ultrasound scan, enhanced abdominal CT scan, and ultrasound-guided fine-needle aspiration biopsy revealed pancreatic metastasis secondary to nasal lymphoma. Radiotherapy (40 Gy) to the whole pancreas was done, followed by two courses of the SMILE regime chemotherapy, leading to a complete remission. At the moment, the patient is undergoing subsequent chemotherapy.
我们在此报告一例鼻型自然杀伤/T细胞淋巴瘤伴胰腺转移的病例。一名43岁的中国女性患者出现右侧鼻塞和脓性鼻漏，持续半年，尽管接受了抗生素治疗，但症状逐渐加重。体格检查发现右侧鼻腔有肿物，右侧颌下区淋巴结肿大。PET/CT扫描及切除标本的免疫染色结果确诊为鼻型自然杀伤/T细胞淋巴瘤，临床分期为IIE期，国际预后指数评分为1分。患者接受了放疗，随后进行了4个周期的CHOP化疗。达到完全缓解，患者无病生存9个月。在随后的随访中，腹部超声扫描、增强腹部CT扫描及超声引导下细针穿刺活检显示为鼻淋巴瘤继发胰腺转移。对整个胰腺进行了40 Gy的放疗，随后进行了两个疗程的SMILE方案化疗，再次达到完全缓解。目前，患者正在接受后续化疗。
