Sevier Carolyn S, Kaiser Chris A
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Nat Rev Mol Cell Biol. 2002 Nov;3(11):836-47. doi: 10.1038/nrm954.
Protein disulphide bonds are formed in the endoplasmic reticulum of eukaryotic cells and the periplasmic space of prokaryotic cells. The main pathways that catalyse the formation of protein disulphide bonds in prokaryotes and eukaryotes are remarkably similar, and they share several mechanistic features. The recent identification of new redox-active proteins in humans and yeast that mechanistically parallel the more established redox-active enzymes indicates that there might be further uncharacterized redox pathways throughout the cell.
蛋白质二硫键在真核细胞的内质网和原核细胞的周质空间中形成。在原核生物和真核生物中催化蛋白质二硫键形成的主要途径非常相似，并且它们具有几个共同的机制特征。最近在人类和酵母中鉴定出的新的氧化还原活性蛋白，其机制与更成熟的氧化还原活性酶相似，这表明整个细胞中可能存在进一步未被表征的氧化还原途径。
